Drug delivery options and therapeutic advances in the management of erectile dysfunction.

Expert Opinion on Drug Delivery
P T GriceV Modgil

Abstract

Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is estimated that 20-30% of adult men will have at least one episode of ED during their lifetime and the prevalence increases with age. ED is known to have significant negative psychological implications for men, resulting in impaired functional status and a greater prevalence of anxiety and depression. Medications for the treatment of erectile dysfunction largely revolve around oral, injection, and topical therapies. Though all three modalities are widely used, each delivery option has its own advantages and specific indications. Likewise, there are several new developing treatments for ED that may change the landscape of treatment. The goal of this review is to summarize contemporary drug delivery options used in the treatment of ED and highlight future promising pharmacological developments. There are a myriad of new developments on the horizon including new PDE5Is and drug targets, nanotechnology enhancements, stem cell and gene therapy, shockwave therapy, and platelet-rich plasma injections. These are all promising new methods to not only treat ED but also to address the pathology and ...Continue Reading

References

May 15, 1998·The New England Journal of Medicine·I GoldsteinP A Wicker
Oct 18, 2000·International Journal of Impotence Research·H WessellsV Hruby
Jun 9, 2005·The Annals of Pharmacotherapy·Stephen M SetterDanial E Baker
Jan 18, 2006·Clinical Science·Liming Jin, Arthur L Burnett
Feb 21, 2006·British Journal of Clinical Pharmacology·S Thomas ForgueMalcolm I Mitchell
Feb 2, 2008·The Journal of Sexual Medicine·Trinity J Bivalacqua, Travis D Strong
Mar 6, 2008·British Journal of Clinical Pharmacology·Bo-Hyung KimIn-Jin Jang
May 20, 2008·BJU International·W Wallace Dinsmore, Michael G Wyllie
Jan 20, 2009·Asian Journal of Andrology·Xie-Gang DingYi Luo
Sep 22, 2009·The Journal of Sexual Medicine·George HanKelvin P Davies
Dec 8, 2011·The Journal of Sexual Medicine·Maarten AlbersenJeffrey L Spees
Oct 9, 2012·Lancet·Rany Shamloul, Hussein Ghanem
Nov 23, 2012·Drugs·Pierre Costa, Axel-Juerg Potempa
Jan 25, 2013·The Journal of Sexual Medicine·Hartmut PorstUNKNOWN ISSM Standards Committee for Sexual Medicine
Dec 27, 2013·Expert Opinion on Pharmacotherapy·Vishwanath Hanchanale, Ian Eardley
Jan 23, 2014·Clinical Therapeutics·Bharat DamleRobert R LaBadie
Mar 6, 2015·Expert Opinion on Emerging Drugs·Taylor C PeakWayne J G Hellstrom
May 15, 2015·The Journal of Sexual Medicine·Mohit KheraJohn P Mulhall
Nov 8, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·James GuoAlan D Widgerow
Sep 1, 2013·Arab Journal of Urology·Sree H MandavaWayne J G Hellstrom
Dec 10, 2015·Expert Opinion on Drug Safety·Giovanni CoronaMario Maggi
Apr 2, 2016·Therapeutic Advances in Urology·Min Chul Cho, Jae-Seung Paick
Apr 27, 2016·The Journal of Sexual Medicine·Irwin GoldsteinJed C Kaminetsky

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Citations

Sep 20, 2020·Journal of Clinical Medicine·George T KediaAndreas Bannowsky
Apr 4, 2021·Biomedicines·Eva AusóGema Esquiva

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