Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment

Journal of Controlled Release : Official Journal of the Controlled Release Society
Antoinette G NelsonP J Sinko

Abstract

The year 2016 will mark an important milestone - the 35th anniversary of the first reported cases of HIV/AIDS. Antiretroviral Therapy (ART) including Highly Active Antiretroviral Therapy (HAART) drug regimens is widely considered to be one of the greatest achievements in therapeutic drug research having transformed HIV infection into a chronically managed disease. Unfortunately, the lack of widespread preventive measures and the inability to eradicate HIV from infected cells highlight the significant challenges remaining today. Moving forward there are at least three high priority goals for anti-HIV drug delivery (DD) research: (1) to prevent new HIV infections from occurring, (2) to facilitate a functional cure, i.e., when HIV is present but the body controls it without drugs and (3) to eradicate established infection. Pre-exposure Prophylaxis (PrEP) represents a significant step forward in preventing the establishment of chronic HIV infection. However, the ultimate success of PrEP will depend on achieving sustained antiretroviral (ARV) tissue concentrations and will require strict patient adherence to the regimen. While first generation long acting/extended release (LA/ER) DD Systems (DDS) currently in development show consid...Continue Reading

Citations

Jul 17, 2019·Drugs·Ioannis Hodges-MameletzisRachel Baggaley
May 18, 2016·Journal of Drug Delivery·Faithful Makita-ChingombeCharles C Maponga
Aug 4, 2019·Pharmaceutics·M Melissa PeetMeredith R Clark
Sep 30, 2020·Current Pathobiology Reports·Adrianne L JennerMorgan Craig
Jul 5, 2016·Chinese Medicine·Gao-Hong ZhangYong-Tang Zheng
Jun 15, 2017·Drug Delivery and Translational Research·William R LykinsTejal A Desai
Nov 12, 2020·Current Opinion in Pharmacology·Yali SangFener Chen
Nov 27, 2020·Future Journal of Pharmaceutical Sciences·Margaret O IlomuanyaAlani S Akanmu

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