Drug Delivery Strategies for Antivirals against Hepatitis B Virus

Viruses
Latavia SinghViness Pillay

Abstract

Chronic hepatitis B virus (HBV) infection poses a significant health challenge due to associated morbidity and mortality from cirrhosis and hepatocellular cancer that eventually results in the breakdown of liver functionality. Nanotechnology has the potential to play a pivotal role in reducing viral load levels and drug-resistant HBV through drug targeting, thus reducing the rate of evolution of the disease. Apart from tissue targeting, intracellular delivery of a wide range of drugs is necessary to exert a therapeutic action in the affected organelles. This review encompasses the strategies and techniques that have been utilized to target the HBV-infected nuclei in liver hepatocytes, with a significant look at the new insights and most recent advances in drug carriers and their role in anti-HBV therapy.

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Citations

Apr 29, 2020·Expert Review of Clinical Immunology·Mario Di GioacchinoLuca Di Giampaolo
Nov 18, 2019·Advanced Drug Delivery Reviews·Xiaozhong HuangHanry Yu

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Methods Mentioned

BETA
transgenic
fluorescence microscopy
nanoprecipitation
transfection

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