Drug Delivery System for Emodin Based on Mesoporous Silica SBA-15

Nanomaterials
Tamara KrajnovićGoran N Kaluđerović

Abstract

In this study mesoporous silica SBA-15 was evaluated as a vehicle for the transport of cytotoxic natural product emodin (EO). SBA-15 was loaded with different quantities of EO (SBA-15|EO1⁻SBA-15|EO5: 8⁻36%) and characterized by traditional methods. Several parameters (stabilities) and the in vitro behavior on tumor cell lines (melanoma A375, B16 and B16F10) were investigated. SBA-15 suppresses EO release in extremely acidic milieu, pointing out that EO will not be discharged in the stomach. Furthermore, SBA-15 protects EO from photodecomposition. In vitro studies showed a dose dependent decrease of cellular viability which is directly correlated with an increasing amount of EO in SBA-15 for up to 27% of EO, while a constant activity for 32% and 36% of EO in SBA-15 was observed. Additionally, SBA-15 loaded with EO (SBA-15|EO3) does not disturb viability of peritoneal macrophages. SBA-15|EO3 causes inhibition of tumor cell proliferation and triggers apoptosis, connected with caspase activation, upregulation of Bax, as well as Bcl-2 and Bim downregulation along with amplification of poly-(ADP-ribose)-polymerase (PARP) cleavage fragment. Thus, the mesoporous SBA-15 is a promising carrier of the water-insoluble drug emodin.

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Citations

Feb 14, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Danijela Maksimović-IvanićSanja Mijatović
Apr 24, 2019·Cancer Cell International·Ian T SaundersShailesh Singh
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Jan 15, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Vinicius RosaNikolaos Silikas
Jun 3, 2021·Cancers·Esra Küpeli AkkolRaffaele Capasso
Dec 9, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Ivana PredarskaEvamarie Hey-Hawkins

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Methods Mentioned

BETA
X-ray
flow cytometry
lavage
fluorescence microscopy

Software Mentioned

CyFlow Space Partec
Partec FloMax
Cell Quest Pro
PartecFloMax

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