PMID: 8953256Nov 1, 1996Paper

Drug delivery to brain tumors

Bulletin of Mathematical Biology
W L Walker, J Cook

Abstract

We develop a macroscopic model for delivering drug to brain tumors. The model accounts for bulk convective and diffusive transport across the blood-brain barrier and through the interstitial space. Through mathematical analysis and simulations, we assess the effects of changing parameters (within physiological bounds) on drug delivery. We find that there is an optimal treatment for convective drug delivery to the center of the tumor. We interpret this phenomenon in terms of traffic flow. The implications of our analyses on existing chemotherapeutic protocols are discussed.

References

Sep 1, 1992·Journal of Neurosurgery·C C ChioK L Black
Jan 1, 1990·Neurologia Medico-chirurgica·T NagashimaS I Rapoport
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P J Robinson, S I Rapoport
May 1, 1986·Microvascular Research·L E Gerlowski, R K Jain
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H NakagawaR G Blasberg
Jul 1, 1994·Scientific American·R K Jain

❮ Previous
Next ❯

Citations

Jun 12, 2013·Expert Opinion on Drug Delivery·Ann-Marie ChackoVladimir Muzykantov
Dec 21, 2000·Current Oncology Reports·R CiordiaT Batchelor
Jun 23, 2009·Expert Opinion on Drug Delivery·Jill M Stukel, Michael R Caplan
Mar 28, 2008·Journal of Drug Targeting·Jill M StukelStephen I Helms Tillery
Apr 22, 2008·Annals of Biomedical Engineering·Jill M StukelMichael R Caplan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.