Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

Chemical Communications : Chem Comm
Daniel HofmannVolker Mailänder

Abstract

Nearly all concepts of nanocarriers as drug delivery devices rely on intracellular uptake. Instead, we demonstrate an alternative concept for rapid and specific delivery of cargo by nanoparticles to TIP47+/ADRP+ lipid droplets. The model can serve as a novel strategy for the non-invasive delivery of drugs by releasing hydrophobic cargo, in our case a model dye, through a kiss-and-run mechanism between nanoparticles and the cell membrane.

References

Jun 4, 1999·Seminars in Cell & Developmental Biology·C LondosA R Kimmel
Mar 12, 2003·Advanced Drug Delivery Reviews·Jayanth Panyam, Vinod Labhasetwar
Jul 1, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·K G de BruinC Bräuchle
Mar 21, 2009·Bioorganic & Medicinal Chemistry·Amir H Faraji, Peter Wipf
May 20, 2009·The Journal of Cell Biology·Anna V BulankinaStefan Höning
Dec 1, 2009·Cell·Robert V Farese, Tobias C Walther
Nov 13, 2010·Biomaterials·Anjali SharmaDusica Maysinger
Jan 11, 2013·Journal of the American Chemical Society·Anna LesniakChristoffer Åberg
Jul 17, 2013·Annals of the New York Academy of Sciences·Mary Ann AugustinTrevor Lockett

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Citations

Jul 15, 2015·Contrast Media & Molecular Imaging·Sandro EbertKerstin Münnemann
Oct 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rozhin PenjweiniAnitha Ethirajan
Sep 1, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brittany L BanikJustin L Brown
Apr 15, 2016·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sofie SnipstadAndreas K O Åslund
Mar 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Evandro M AlexandrinoFrederik R Wurm
May 13, 2020·Pharmaceutical Research·Baptiste MartinSophie Franceschi
Jan 1, 2014·Cancer Nanotechnology·Sofie SnipstadCatharina de Lange Davies
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Federica De GaetanoRosanna Stancanelli
Mar 29, 2021·Biosensors & Bioelectronics·Qing GaoBaojun Li
Apr 20, 2021·ACS Biomaterials Science & Engineering·Suguna PerumalIn Woo Cheong
Jun 12, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Enqi ZhangPetra Henrich-Noack
Jul 16, 2021·Nanoscale·Kristen N SikoraRichard W Vachet
Aug 21, 2020·Journal of Colloid and Interface Science·Martijn PetersAnitha Ethirajan
Dec 12, 2019·Analytical Chemistry·Kristen N SikoraRichard W Vachet
Mar 7, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Anders UtoftDavid Needham

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