PMID: 3770590Aug 1, 1986Paper

Drug dependence tests on a new anesthesia inducer, midazolam

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
A KubotaK Nakamura

Abstract

Drug dependence tests on a new intravenous anesthesia inducer midazolam were performed in comparison with triazolam in male cynomolgus monkeys utilizing the intravenous route of administration. In the animals trained to self-administer sodium pentobarbital (0.6-1 mg/kg/inj) under FR1 and FR10 reinforcement schedules, 0.01 midazolam and 0.001 mg/kg/inj triazolam maintained self-administration in more than 4 out of 5 animals under FR1. Doses of 0.03 and 0.001 mg/kg/inj, respectively, were required under FR10. The intradaily progressive ratio test revealed that midazolam maintained self-administration only weakly (equivalently as or more weakly than triazolam did). Midazolam at 0.003-0.1 and triazolam at 0.0003-0.01 mg/kg/inj initiated self-administration, respectively, in 3 and 1 out of 4 naive animals, but the numbers of self-administration responses were only slightly higher than the vehicle control level. Pentobarbital at 0.1-3 mg/kg initiated self-administration in all of 4 animals with a high level of self-administration. In the single dose suppression test in physically pentobarbital-dependent animals, an ED25 value of midazolam for the suppression of the withdrawal signs was 0.30 mg/kg, i.v., which was almost equivalent to...Continue Reading

Citations

Jun 1, 1987·Pharmacology, Biochemistry, and Behavior·N A Ator, R R Griffiths
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·J L Falk, M Tang

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