Drug development strategies for asthma: in search of a new paradigm

Nature Immunology
P G HoltU Wahn

Abstract

The spiraling costs of asthma treatment seem set to continue rising, given the equivocal performance of the latest generation of specific anti-inflammatory drugs in trials in adult asthmatics. We argue that the continuation of this trend is inevitable unless there is a substantial realignment of entrenched drug development policy in the pharmaceutical industry and a parallel shift in licensing policy by regulatory authorities to encourage the development of drugs capable of halting the progression from acute to chronic asthma when the disease first manifests in childhood. The theoretical framework for such an approach, including proof-of-principle data from studies in children with early-stage disease and a range of candidate drugs, already exists. What is needed is informed debate on the risks versus potential benefits of this approach.

References

Dec 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G HoltW R Thomas
Jan 1, 1990·Pediatric Pulmonology·M E HibbertP D Phelan
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·F D Martinez
Sep 1, 1996·American Journal of Respiratory and Critical Care Medicine·S L JohnstonS T Holgate
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T Holgate
Jun 26, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D SherrillF Martinez
Sep 13, 2000·The Journal of Allergy and Clinical Immunology·G P Giacoia
Oct 12, 2000·The New England Journal of Medicine·UNKNOWN Childhood Asthma Management Program Research GroupRobert Zeiger
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·K B Weiss, S D Sullivan
Jun 23, 2001·The New England Journal of Medicine·C B Hall
Oct 9, 2001·The Journal of Allergy and Clinical Immunology·B BjörksténM Mikelsaar
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Christian MöllerUlrich Wahn
Apr 9, 2002·The European Respiratory Journal·P G Holt, P D Sly
May 22, 2002·Indian Journal of Pediatrics·H Paramesh
Sep 20, 2002·The New England Journal of Medicine·Charlotte Braun-FahrländerUNKNOWN Allergy and Endotoxin Study Team
Sep 21, 2002·Lancet·Roger P LauenerUNKNOWN ALEX study group
Oct 3, 2002·The European Respiratory Journal·P ErnstM R Becklake
Nov 20, 2002·The Journal of Experimental Medicine·Fiona J CulleyPeter J M Openshaw
Oct 10, 2003·The New England Journal of Medicine·Fernando D Martinez

❮ Previous
Next ❯

Citations

May 28, 2008·Expert Reviews in Molecular Medicine·Bennett O V ShumWilliam A Sewell
Jan 22, 2008·Nature Reviews. Immunology·Patrick G HoltFrode L Jahnsen
Jun 22, 2005·The Journal of Experimental Medicine·Robert L Coffman, Edith M Hessel
Dec 23, 2009·The Journal of Experimental Medicine·Amy Maxmen
Dec 14, 2004·Current Opinion in Pulmonary Medicine·Anne E Dixon, Charles G Irvin
Nov 19, 2004·Current Opinion in Pediatrics·Stephanie C EisenbarthKim Bottomly
Jul 9, 2005·American Journal of Respiratory and Critical Care Medicine·Peter D SlyZoltan Hantos
Sep 23, 2006·American Journal of Respiratory Cell and Molecular Biology·James G KarrasSusan A Gregory
Jun 7, 2005·Clinical and Molecular Allergy : CMA·Matthias Wjst
Mar 5, 2008·Journal of Occupational Medicine and Toxicology·Armin BraunDavid A Groneberg
Mar 23, 2010·The Journal of Allergy and Clinical Immunology·Sylvie AmuPadraic G Fallon
Oct 31, 2009·Allergologia et immunopathologia·F D Martinez
Sep 8, 2009·The Journal of Allergy and Clinical Immunology·Elysia M HollamsPatrick G Holt
May 19, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Giovanni B Pajno
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G Holt, P D Sly
Oct 1, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Mónica AbellaManuel Desco
Apr 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W FeleszkoE Hamelmann
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L ConejeroJ M Zubeldia
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S W TurnerP G Holt
Oct 7, 2004·Trends in Molecular Medicine·Talal A Chatila
Aug 29, 2006·Lancet·Sabina IlliUNKNOWN Multicentre Allergy Study (MAS) group
Jan 27, 2006·European Journal of Pharmacology·Wojciech FeleszkoEckard Hamelmann
Sep 27, 2006·The American Journal of Medicine·Tomoko Hayashi, Eyal Raz
Sep 7, 2004·Journal of Applied Physiology·Mai-Uyen T TranCharles G Plopper
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomoko HayashiEyal Raz
Sep 14, 2007·Annals of Medicine·Lars K Poulsen, Lone Hummelshoj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

American Journal of Respiratory and Critical Care Medicine
B LeynaertEuropean Community Respiratory Health Survey
The New England Journal of Medicine
W W Busse, R F Lemanske
The Journal of Clinical Investigation
J A EliasR J Homer
Clinical & Developmental Immunology
M Wjst
© 2022 Meta ULC. All rights reserved