Drug-Directed Morphology Changes in Polymerization-Induced Self-Assembly (PISA) Influence the Biological Behavior of Nanoparticles.

ACS Applied Materials & Interfaces
Cheng CaoMartina H Stenzel

Abstract

The effect of the hydrophobic block length on the morphologies of polymerization-induced self-assembled (PISA) nanoparticles is well understood. However, the influence of drug loading on the phase morphology of the nanoparticles during the PISA process, and the resulting biological function of PISA nanoparticles, has barely been investigated. In this work, we show that the addition of a drug, curcumin, during the PISA process shifts the phase diagram toward different morphologies. The PISA system was based on hydrophilic poly(2-(methacryloyloxy)ethylphosphorylcholine) (PMPC), which was chain extended with hydrophobic methyl methacrylate (MMA) in various concentrations of curcumin. According to transmission electron microscopy, the presence of curcumin led to the transition of, for example, worms to polymersome and micelles to worms analysis. To understand the interaction between polymer particles and drug, small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), and fluorescence lifetime measurements were carried out. These measurements show that curcumin is predominantly located in the core in the case of micelles and worms while it is found in the shell of polymersomes. The change in morphology influences t...Continue Reading

References

Jan 18, 2006·Life Sciences·Radha K MaheshwariRikhab C Srimal
Feb 22, 1991·Science·S T Milner
Jul 26, 2008·Nature Nanotechnology·Yan GengDennis E Discher
Jan 1, 2008·Journal of Polymer Science. Part A, Polymer Chemistry·Ke ZhangKaren L Wooley
Aug 19, 2011·Journal of the American Chemical Society·Adam BlanazsSteven P Armes
Aug 23, 2011·Journal of the American Chemical Society·Shinji SugiharaAndrew L Lewis
Dec 24, 2011·Journal of the American Chemical Society·Carl D WalkeyWarren C W Chan
Jul 11, 2012·Chemical Society Reviews·Yiyong Mai, Adi Eisenberg
Sep 5, 2013·Journal of the American Chemical Society·Jeppe MadsenSteven P Armes
Nov 22, 2013·Macromolecular Rapid Communications·Bunyamin KaragozThomas P Davis
Apr 24, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Joseph B Schlenoff
Jun 27, 2014·Journal of the American Chemical Society·Nicholas J Warren, Steven P Armes
Jul 17, 2014·Biomaterials·Murali M YallapuSubhash C Chauhan
Feb 7, 2015·International Journal of Oral Science·Ning ZhangHockin Hk Xu
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Oct 16, 2015·Chemical Reviews·Mahmoud ElsabahyKaren L Wooley
Apr 5, 2016·Chemistry of Materials : a Publication of the American Chemical Society·Julien Nicolas
Oct 11, 2016·Chemical Society Reviews·N GrimaldiN Ventosa
Nov 4, 2016·ACS Applied Materials & Interfaces·Yanna CuiYongzhuo Huang
Dec 29, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexander BorehamUlrike Alexiev
Jun 7, 2017·Chemical Society Reviews·Shahed BehzadiMorteza Mahmoudi
Jul 22, 2018·Macromolecular Rapid Communications·Lakshmeesha UpadhyayaMona Semsarilar
Oct 3, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Yousif A Al-DulaijanHockin H K Xu
Oct 24, 2018·Chemical Communications : Chem Comm·Fan ChenMartina Stenzel
Feb 6, 2019·Nature Communications·Sandy WongMartina H Stenzel
Aug 20, 2019·Angewandte Chemie·Axel-Laurenz BuckinxTanja Junkers
Oct 5, 2019·Angewandte Chemie·Franck D'AgostoMuriel Lansalot

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