Drug discovery from uncultivable microorganisms

Drug Discovery Today
Brajesh Kumar Singh, Catriona A Macdonald

Abstract

Environmental microbes are a major source of drug discovery, and several microbial products (antibiotics, anti-tumour products, immunosuppressants and others) are used routinely for human therapies. Most of these products were obtained from cultivable (<1%) environmental microbes, and this means that the vast majority of microbes were not targeted for drug discovery. With the advent of new and emerging technologies, we are poised to harvest novel drugs from the so-called 'uncultivable' microbes. In this article, we propose how a multidisciplinary approach combining different technologies can expedite and revolutionize drug discovery from uncultivable microbes and examine the current limitations of technologies and strategies to overcome such limitations that might further expand the promise of drugs from environmental microbes.

Citations

Jul 23, 2013·Trends in Biotechnology·Miguel C LealRonald Osinga
Apr 19, 2012·The Journal of Antibiotics·János Bérdy
Nov 3, 2010·Nanomedicine·Jie GaoYajun Guo
Dec 18, 2014·ACS Medicinal Chemistry Letters·Verena Grundler, Karl Gademann
Dec 23, 2011·Applied Microbiology and Biotechnology·David Matthias EkkersJan Dirk van Elsas
Mar 14, 2013·Expert Opinion on Drug Discovery·Herbert A Kirst
Sep 17, 2013·Angewandte Chemie·Kieron M G O'ConnellDavid R Spring
Apr 10, 2013·Orvosi hetilap·János Bérdy
May 30, 2013·Journal of Oral Microbiology·José F Siqueira, Isabela N Rôças
May 6, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongqi ZhangKun Zou
Aug 12, 2020·Natural Product Reports·Huomiao Ran, Shu-Ming Li
Apr 24, 2021·Microbiological Research·Gowardhan Kumar ChouhanBrajesh Kumar Singh
Sep 2, 2021·Chemosphere·Sanchali BoseDai-Viet N Vo

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