Drug discovery of neurodegenerative disease through network pharmacology approach in herbs

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zhipeng KeWei Xiao

Abstract

Neurodegenerative diseases, referring to as the progressive loss of structure and function of neurons, constitute one of the major challenges of modern medicine. Traditional Chinese herbs have been used as a major preventive and therapeutic strategy against disease for thousands years. The numerous species of medicinal herbs and Traditional Chinese Medicine (TCM) compound formulas in nervous system disease therapy make it a large chemical resource library for drug discovery. In this work, we collected 7362 kinds of herbs and 58,147 Traditional Chinese medicinal compounds (Tcmcs). The predicted active compounds in herbs have good oral bioavailability and central nervous system (CNS) permeability. The molecular docking and network analysis were employed to analyze the effects of herbs on neurodegenerative diseases. In order to evaluate the predicted efficacy of herbs, automated text mining was utilized to exhaustively search in PubMed by some related keywords. After that, receiver operator characteristic (ROC) curves was used to estimate the accuracy of predictions. Our study suggested that most herbs were distributed in family of Asteraceae, Fabaceae, Lamiaceae and Apocynaceae. The predictive model yielded good sensitivity and s...Continue Reading

References

Mar 29, 2001·Journal of Pharmacological and Toxicological Methods·C A Lipinski
May 15, 2001·Journal of Neurobiology·I AzcoitiaL M Garcia-Segura
Oct 9, 2001·Mechanisms of Ageing and Development·V N Talesa
Oct 11, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Adam D CashMark A Smith
Sep 16, 2003·Neuron·William Dauer, Serge Przedborski
Oct 8, 2003·Current Medicinal Chemistry·Jianhua ShenHualiang Jiang
Jun 8, 2004·Current Drug Metabolism·M LiuN J Alkayed
Jan 3, 2007·Drug Discovery Today·Grant R ZimmermannCurtis T Keith
Feb 14, 2007·Journal of Chemical Information and Modeling·Reiji Teramoto, Hiroaki Fukunishi
Oct 9, 2007·Nature Biotechnology·Muhammed A YildirimMarc Vidal
Mar 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lan WangZhu Chen
Apr 22, 2008·Journal of Natural Medicines·Hideji ItokawaKuo-Hsiung Lee
Jul 1, 2008·Chinese Medicine·Songlin LiHongxi Xu
Jul 11, 2008·Clinical Pharmacology and Therapeutics·W-C HwangM Ramanathan
Sep 10, 2008·Chemistry Central Journal·Xiaohui JiangJaques Reifman
Nov 19, 2008·Journal of Neurology·Francesca Del Sorbo, Alberto Albanese
Oct 22, 2008·Nature Chemical Biology·Andrew L Hopkins
Apr 29, 2009·Journal of Computational Chemistry·Garrett M MorrisArthur J Olson
Jun 22, 2010·Journal of Neural Transmission·Hyman M Schipper
Sep 3, 2010·Phytotherapy Research : PTR·S de Caires, V Steenkamp
May 4, 2011·Progress in Neurobiology·Werner J GeldenhuysCornelis J Van der Schyf
May 24, 2011·Journal of Neurology·Massimiliano FilostoAlessandro Padovani
Jun 4, 2011·BMC Medical Ethics·Julie M RobillardJudy Illes
Jan 14, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Loren PenaJoel Charrow
Apr 26, 2012·CNS Neuroscience & Therapeutics·Valentina Echeverria, Ross Zeitlin
Apr 28, 2012·Biochemical and Biophysical Research Communications·Eun-Ju YangDong-Seok Lee
Jul 13, 2012·Cleveland Clinic Journal of Medicine·Carlos Singer
Nov 8, 2012·Nature Methods·Rintaro SaitoTrey Ideker
Dec 12, 2012·Frontiers in Plant Science·Michel SchneiderSylvain Poux
Dec 13, 2012·Expert Opinion on Drug Discovery·Werner J Geldenhuys, Cornelis J Van der Schyf
Feb 19, 2013·Current Treatment Options in Neurology·Aleksandar Videnovic
Mar 6, 2013·Journal of Medicinal Chemistry·Paul C TrippierRichard B Silverman
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jiangyong GuXiaojie Xu
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ming YangGuang Ji
Oct 15, 2013·Biochimica Et Biophysica Acta·Aaron M SwomleyD Allan Butterfield
Oct 29, 2013·Annual Review of Pharmacology and Toxicology·Christopher LaustedKai Wang
Dec 25, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Samuel Frank
Feb 20, 2014·BioMed Research International·Thanh-Phuong NguyenCorrado Priami
Jan 7, 2015·Annals of Neurology·John C SteeleMatthew J Farrer
Feb 7, 2015·Community Dentistry and Oral Epidemiology·Anelise DaherLuciane R Costa

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Citations

Jan 29, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jinghui WangHuifeng Zhu
Apr 21, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohammad Hassan BaigInho Choi

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