Drug discovery using spirooxindole cores: Success and Challenges [corrected

European Journal of Medicinal Chemistry
Bin YuHong-Min Liu

Abstract

The identification of novel anticancer agents with high efficacy and low toxicity has always been an intriguing topic in medicinal chemistry. The unique structural features of spirooxindoles together with diverse biological activities have made them promising structures in new drug discovery. “Among spirooxindoles, CFI-400945, recently discovered by Sampson et al., is a potent PLK4 inhibitor, which has entered phase I clinical trials for the treatment of solid tumors. However, questions remain as to whether PLK4 is the only relevant therapeutic target for CFI-400945. To highlight this significant progress of CFI-400945 in last two years, this review centers on the identification from a focused kinase library, structural optimizations and strategies involved, structure-activity relationships, modes of action, target validation, chemical synthesis and, more importantly, the kinase selectivity between PLK4 and other targets [corrected].

References

Dec 31, 1998·Genes & Development·D M GloverA A Tavares
Jan 11, 2005·Oncogene·Drew M LoweryMichael B Yaffe
Apr 28, 2005·Current Topics in Medicinal Chemistry·Campbell McInnesPeter M Fischer
Oct 26, 2005·Nature Cell Biology·Robert HabedanckErich A Nigg
Dec 6, 2005·Current Biology : CB·M Bettencourt-DiasD M Glover
Aug 18, 2006·Nature Reviews. Drug Discovery·Norman E Sharpless, Ronald A Depinho
Apr 28, 2007·Biochemistry·Michael KotheYuan-Hua Ding
Jan 27, 2010·The Journal of Cell Biology·Andrew J HollandDon W Cleveland
Mar 23, 2010·Current Opinion in Chemical Biology·Matthew E WelschBrent R Stockwell
Mar 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carla O RosarioCarol J Swallow
Oct 6, 2010·Cell Division·James E Sillibourne, Michel Bornens
Nov 26, 2010·Nature Reviews. Cancer·Susanne M A LensRené H Medema
Oct 12, 2011·The Journal of Cell Biology·Christopher W BrownleeGregory C Rogers
Nov 11, 2011·Journal of Medicinal Chemistry·Matthew O DuffeyNatalie D'Amore
May 18, 2012·Chemical Society Reviews·David Y-K ChenJean-Alexandre Richard
Feb 1, 2010·Expert Opinion on Drug Discovery·Hongyu Zhao, Irini Akritopoulou-Zanze
Jul 6, 2014·European Journal of Medicinal Chemistry·Bin YuHong-Min Liu
Jul 24, 2014·Bioorganic & Medicinal Chemistry Letters·Yajun ZhengSuresh B Singh
Aug 15, 2014·Cancer Cell·Andrew J Holland, Don W Cleveland
Oct 28, 2014·Journal of Medicinal Chemistry·Mija AhnJeong Kyu Bang

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Citations

Aug 25, 2015·European Journal of Medicinal Chemistry·Kishna Ram SenwarNagula Shankaraiah
Apr 23, 2016·European Journal of Medicinal Chemistry·Bin YuHong-Min Liu
Aug 20, 2015·ACS Medicinal Chemistry Letters·P DavidovichV Tribulovich
Jul 17, 2015·ACS Combinatorial Science·Vanesa Giménez-NavarroViktor Krchňák
Feb 13, 2018·Proceedings of the National Academy of Sciences of the United States of America·Masanori KawakamiEthan Dmitrovsky
Nov 25, 2017·Expert Opinion on Therapeutic Targets·Radhika Radha ManiswamiSooriya Kumar Jegatheesan
May 18, 2018·Chemical Communications : Chem Comm·Guang-Jian Mei, Feng Shi
Jun 25, 2016·Beilstein Journal of Organic Chemistry·Bin YuHong-Min Liu
Feb 29, 2020·Expert Opinion on Drug Discovery·Li-Ming ZhouGuang-Fu Yang
Aug 27, 2019·Frontiers in Chemistry·Manuel A Rentería-GómezRocío Gámez-Montaño
Sep 19, 2020·Organic & Biomolecular Chemistry·Bruno Boni GuidottiFernando Coelho
Nov 8, 2018·Bioengineering·Anders W BaileySimone Treiger Sredni
Jul 21, 2021·The Journal of Organic Chemistry·Vojtěch DočekalJan Veselý
Feb 20, 2019·The Journal of Organic Chemistry·Cong-Shuai WangFeng Shi

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