Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors

The Journal of Pharmacology and Experimental Therapeutics
Paul W CzotyJack Bergman

Abstract

The involvement of brain monoamine systems in the discriminative stimulus effects of methamphetamine (MA) was studied in squirrel monkeys by evaluating the effects of differentially selective monoamine uptake inhibitors alone and in combination. In monkeys discriminating i.m. injections of 0.3 mg/kg MA from saline, methamphetamine (0.01-0.3 mg/kg), and dopamine transporter (DAT) inhibitors, including 1-[2-(bis(4-fluorophenyl)-methoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909; 1.0-17.8 mg/kg) and its analogs AM2502 (1.0-17.8 mg/kg), AM2506 (1.0-30.0 mg/kg), AM2515 (1.0-17.8 mg/kg), and AM2517 (1.0-5.6 mg/kg), produced dose-related increases in responding on the MA-associated lever and, at the highest doses, full substitution. The time course of MA-like effects was similar for equivalent (3.0 mg/kg) doses of GBR 12909 and its most potent analog, AM2517. Unlike the DAT blockers, the selective 5-hydroxytryptamine (serotonin) uptake inhibitor clomipramine (1.0-10.0 mg/kg) and the selective norepinepherine (NE) uptake inhibitor desipramine (1.0-10 mg/kg) produced responding primarily on the saline lever. The selective NE uptake inhibitor nisoxetine partially substituted at the highest dose tested (10.0 mg/kg). Pretreatment with ...Continue Reading

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Citations

May 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janusz BoryczSergi Ferré
Dec 24, 2008·The Journal of Pharmacology and Experimental Therapeutics·Rajkumar J SevakCraig R Rush
Sep 3, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·William W StoopsCraig R Rush
Oct 27, 2007·Drug and Alcohol Dependence·Michael B GatchMichael J Forster
Mar 6, 2010·Annals of the New York Academy of Sciences·David V HerinJohn Grabowski
Jun 27, 2014·Journal of the Experimental Analysis of Behavior·B Levi BolinChana K Akins
Nov 6, 2012·European Journal of Pharmacology·Jun-Xu LiChunyang Jin
Feb 25, 2015·Drug and Alcohol Dependence·Jennifer E NaylorSally L Huskinson
May 17, 2007·The Journal of Pharmacology and Experimental Therapeutics·Donna M PlattRoger D Spealman
Apr 29, 2021·The International Journal of Neuropsychopharmacology·Alison G P WakefordCarol A Paronis

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