PMID: 2859972Feb 1, 1985

Drug discrimination studies

Drug and Alcohol Dependence
S G Holtzman

Abstract

Opioid agonists and agonist/antagonists comprise a heterogeneous body of compounds that can be partitioned into at least three groups on the basis of their discriminative stimulus properties in several animal species: (1) stimulus effects similar to those of morphine or fentanyl and blocked completely by low doses of antagonists, such as naloxone and naltrexone; (2) stimulus effects similar to those of ethylketocyclazocine or nalorphine and blocked by higher doses of antagonists; (3) stimulus effects similar to those N-allylnormetazocine or phencyclidine and not blocked by antagonists. This diversity of stimulus properties is consistent with other evidence that multiple populations of receptors mediate the actions of opioids. In man, drugs in group 1 produce subjective effects that are entirely morphine-like and highly reinforcing whereas drugs in groups 2 and 3 produce dysphoric and psychotomimetic subjective effects. Thus, discriminative stimulus properties of opioids appear to reflect drug actions at the neuronal level that are directly relevant to potential for abuse in man.

References

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Citations

Jan 1, 1987·Psychopharmacology·M W Emmett-Oglesby, A Herz
Jan 1, 1996·Psychopharmacology·J A White, I P Stolerman
May 29, 2004·Psychopharmacology·Torbjörn U C JärbeAlexandros Makriyannis
Nov 25, 2005·Psychopharmacology·Torbjörn U C JärbeAlexandros Makriyannis
Dec 12, 1989·European Journal of Pharmacology·N NishidaM Fujino
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·M T BardoR C Pierce
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·D White-Gbadebo, S G Holtzman
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley
Nov 1, 1992·Behavioral and Neural Biology·D M Skinner, G M Martin
Jan 1, 1990·Pharmacology & Therapeutics·J S Andrews, D N Stephens
Jul 1, 1992·Trends in Pharmacological Sciences·James H WoodsC P France
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Liana FattoreWalter Fratta
May 22, 2003·Drug and Alcohol Dependence·Robert L Balster, George E Bigelow
Jan 10, 1997·Drug and Alcohol Dependence·E A MariathasanJ A White
Jun 1, 1996·Drug and Alcohol Review·J M White, C F Ryan
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Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Barbara J CaldaroneAfshin Ghavami
Jul 7, 2011·The Journal of Pharmacology and Experimental Therapeutics·Emily M JutkiewiczJames H Woods
Jul 12, 2012·Biochemical Pharmacology·Amy Hauck NewmanPhil Skolnick
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·G J Schaefer
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Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Carrie A BowenS Stevens Negus

Related Concepts

SK&F 10047, monooxalate
Opioids
Metazoa
Discrimination (Process of Differentiation)
Dose-Response Relationship, Drug
Sublimaze
Generalization, Stimulus
Macaca mulatta
Morphine Sulfate (2: 1), Pentahydrate
Nalorphine, L-tartrate (1: 1)

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