Drug dosing in the critically ill obese patient-a focus on sedation, analgesia, and delirium.

Critical Care : the Official Journal of the Critical Care Forum
Brian L Erstad, Jeffrey F Barletta

Abstract

Practice guidelines provide clear evidence-based recommendations for the use of drug therapy to manage pain, agitation, and delirium associated with critical illness. Dosing recommendations however are often based on strategies used in patients with normal body habitus. Recommendations specific to critically ill patients with extreme obesity are lacking. Nonetheless, clinicians must craft dosing regimens for this population. This paper is intended to help clinicians design initial dosing regimens for medications commonly used in the management of pain, agitation, and delirium in critically ill patients with extreme obesity. A detailed literature search was conducted with an emphasis on obesity, pharmacokinetics, and dosing. Relevant manuscripts were reviewed and strategies for dosing are provided.

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Citations

Sep 22, 2020·Seminars in Respiratory and Critical Care Medicine·Yahya ShehabiBelinda Howe
Feb 25, 2021·Critical Care : the Official Journal of the Critical Care Forum·Brian L Erstad, Jeffrey F Barletta
Oct 2, 2020·Current Opinion in Critical Care·Damaris Ortiz
Jun 11, 2021·Journal of Pharmacy Practice·Sara A AtyiaCasey C May
May 17, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Aditi BalakrishnaEdward A Bittner
Aug 9, 2021·Chest·Michaela R Anderson, Michael G S Shashaty

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Methods Mentioned

BETA
sedation

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