Drug-Eluting Balloons versus Second-Generation Drug-Eluting Stents for Treating In-Stent Restenosis in Coronary Heart Disease after PCI: A Meta-Analysis

Cardiology Research and Practice
Wen-Juan XiuXiang Xie

Abstract

In-stent restenosis (ISR) remains a common problem following percutaneous coronary intervention (PCI). However, the best treatment strategy remains uncertain. There is some controversy over the efficacy of drug-eluting balloons (DEBs) and second-generation drug-eluting stents (DESs) for treating ISR. A meta-analysis was used to compare the efficacy of the DEB and second-generation DES in the treatment of ISR. The primary endpoint is the incidence of target lesion revascularization (TLR). The secondary endpoint is the occurrence of target vessel revascularization (TVR), myocardial infarction (MI), all-cause death (ACM), cardiac death (CD), major adverse cardiac events (MACEs), minimum luminal diameter (MLD), late luminal loss (LLL), binary restenosis (BR), and percent diameter stenosis (DS%). A total of 12 studies (4 randomized controlled trials and 8 observational studies) including 2020 patients with a follow-up of 6-25 months were included in the present study. There was a significant difference in the MLD between the two groups during follow-up (P=0.007, RR = 0.23, and 95% CI: 0.06-0.4 mm). There was no significant difference in LLL, BR, or DS% and the overall incidence of MACEs between the two groups. Subgroup analysis show...Continue Reading

References

Sep 9, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Sudhir RathoreTakahiko Suzuki
Nov 27, 2010·Journal of the American College of Cardiology·George D DangasRoxana Mehran
Apr 21, 2011·Circulation. Cardiovascular Interventions·Vasim FarooqPatrick W Serruys
Jul 21, 2012·JACC. Cardiovascular Interventions·Fernando AlfonsoUNKNOWN RIBS-III Study Investigators (under the auspices of the Working Group on Interventional Cardiology of the Spanish Society of
Jun 15, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mohammad AlmallaRainer Hoffmann
Jan 15, 2014·Journal of the American College of Cardiology·Fernando AlfonsoUNKNOWN RIBS V Study Investigators, under the auspices of the Working Group on Interventional Cardiology of the Spanish Society of C
Aug 21, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tom AdriaenssensWalter Desmet
Nov 19, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Toru NaganumaAntonio Colombo
Dec 3, 2014·JACC. Cardiovascular Interventions·Yaling HanUNKNOWN I-LOVE-IT 2 Investigators
Jan 21, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Shunsuke KuboKazuaki Mitsudo
Jul 4, 2015·Journal of the American College of Cardiology·Fernando AlfonsoUNKNOWN RIBS IV Study Investigators (under auspices of Interventional Cardiology Working Group of Spanish Society of Cardiology)
Oct 21, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sandeep BasavarajaiahAntonio Colombo

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