Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model

Journal of Vascular and Interventional Radiology : JVIR
J NamurAlexandre Laurent

Abstract

To evaluate the local tissue concentrations of the antineoplastic agent doxorubicin and the amount of drug still present inside drug delivery embolization beads at different time points after embolization and to compare doxorubicin levels with histologic modifications around the beads in a pig liver model. It was hypothesized that doxorubicin-eluting beads maintain cytotoxic concentrations of drug locally over a period of several weeks, as suggested by in vitro elution tests. Left lobe hepatic artery embolization was performed in 10 pigs with 100-300-microm or 700-900-microm beads loaded with 37.5 mg doxorubicin/mL. Control unloaded 100-300-microm beads were injected in five pigs. Livers were sampled 28 days or 90 days after embolization. The amount of drug retained inside the beads was assessed with infrared microspectroscopy. Doxorubicin concentration and distribution in the tissue around the beads were determined with microspectrofluorimetry and compared with tissue modifications on hematein eosin saffron-stained sections. Doxorubicin-eluting beads eluted 43% of their initial drug load after 28 days and 89% after 90 days. Doxorubicin was present in tissues around the beads at both time points, with a significant decrease ove...Continue Reading

References

Aug 1, 1986·Seminars in Liver Disease·T Nakashima, M Kojiro
May 6, 1988·Biochimica Et Biophysica Acta·M GigliM Manfait
Jan 13, 1997·Biochemical and Biophysical Research Communications·I MüllerB Halliwell
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·S W YiS Y Jeong
Aug 4, 2001·European Journal of Cell Biology·A MaillouxB Baudin
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·J L AuM G Wientjes
Sep 5, 2002·Journal of Biomedical Materials Research·Jinming GaoJohn Haaga
Jan 24, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Josep M Llovet, Jordi Bruix
Oct 8, 2003·The Oncologist·Keith Stuart
May 6, 2004·Journal of Vascular and Interventional Radiology : JVIR·Alexandre LaurentJean-Jacques Merland
May 6, 2004·Journal of Biomedical Materials Research. Part a·Elvin BlancoJinming Gao
Jun 7, 2005·Biochimica Et Biophysica Acta·Ali TfayliMichel Manfait
Mar 7, 2006·Journal of Vascular and Interventional Radiology : JVIR·Andrew L LewisPeter W Stratford
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kelvin HongJean-Francois H Geschwind
Jul 25, 2006·Nature Reviews. Cancer·Andrew I Minchinton, Ian F Tannock
Aug 23, 2006·Journal of Vascular and Interventional Radiology : JVIR·Andrew L LewisPeter W Stratford
Sep 29, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brent D WeinbergJinming Gao
Feb 26, 2008·Journal of Vascular and Interventional Radiology : JVIR·Wen-Sheng TzengChi-Hung Lin
Apr 16, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·J NamurA Laurent
Jul 4, 2009·Expert Review of Medical Devices·Andrew L Lewis

❮ Previous
Next ❯

Citations

Oct 12, 2012·Abdominal Imaging·Juan Carlos SpinaRicardo García-Mónaco
Dec 12, 2012·Cardiovascular and Interventional Radiology·Sylvain FavelierBoris Guiu
Feb 18, 2010·Journal of Materials Science. Materials in Medicine·Steffen BaltesThomas Brinker
Sep 24, 2011·AJR. American Journal of Roentgenology·Rajesh P ShahConstantinos T Sofocleous
Aug 6, 2014·Nature Reviews. Clinical Oncology·Alejandro FornerJean-Luc Raoul
Jun 23, 2011·Expert Opinion on Drug Delivery·Antonio NicoliniLaura Martinetti
Dec 18, 2015·Journal of Materials Science. Materials in Medicine·Andrew L LewisBradford J Wood
Jan 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andrew L Lewis, Matthew R Dreher
Dec 20, 2011·Journal of Vascular and Interventional Radiology : JVIR·Matthew R DreherBradford J Wood
Dec 20, 2011·Journal of Vascular and Interventional Radiology : JVIR·Ron C GabaReed A Omary
Nov 10, 2015·Journal of Vascular and Interventional Radiology : JVIR·Carmen Gacchina JohnsonKarun V Sharma
Oct 6, 2011·Academic Radiology·Michael C CochranMargaret A Wheatley
Feb 19, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Valentin VerretAlexandre Laurent
Mar 13, 2016·Drug Discovery Today·Farshad RamazaniRobbert J Kok
Jun 10, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Minh-Tâm BaylatryAlex Laurent
Sep 20, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E JubeliL Moine
Mar 1, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Azadeh PoursaidHamidreza Ghandehari
Jun 4, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki SandaShinichi Murata
May 23, 2015·Diagnostic and Interventional Imaging·C AubéF Oberti
Feb 24, 2015·Journal of Vascular and Interventional Radiology : JVIR·Amy R DeipolyiSuvranu Ganguli
Jun 14, 2016·Molecular Pharmaceutics·Azadeh PoursaidHamidreza Ghandehari
Aug 16, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tanya SwaineAndrew L Lewis
Sep 25, 2010·International Journal of Pharmaceutics·S Vinchon-PetitP Menei
Feb 3, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen T BrownGhassan K Abou-Alfa
May 2, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Florentina PascaleAlexandre Laurent
May 26, 2017·Anti-cancer Drugs·Cressida BowyerWendy M Macfarlane
Jun 29, 2018·Future Oncology·Julien DelicqueChristophe Cassinotto
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Mar 25, 2020·The Cancer Journal·Nikitha MuraliHyun S Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.