Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma

Journal of Gastroenterology and Hepatology
Antonio FacciorussoVincenzo Mazzaferro

Abstract

Solid demonstrations of superior efficacy of drug-eluting beads transarterial chemoembolization with respect to conventional chemoembolization in hepatocellular carcinoma patients are lacking. The aim of the study was to compare these two techniques in two large cohorts of unresectable hepatocellular carcinoma patients. A single center series of 249 early/intermediate hepatocellular carcinoma patients who underwent "on demand" chemoembolization in the period 2007-2011 was analyzed. Overall survival, time to progression, tumor response rate, and safety were compared between 104 patients who underwent conventional chemoembolization and 145 who underwent drug-eluting beads chemoembolization. Time-to-event data were analyzed using the Cox univariate and multivariate regression. The two cohorts resulted balanced for liver function and tumor stages. Objective response rate was 85.3% after conventional and 74.8% after drug-eluting beads chemoembolization (P = 0.039), and median time to progression was 17 (95% confidence interval: 14-21) versus 11 months (9-12), respectively (P < 0.001). Treatment regimen was the sole independent predictor of progression at multivariate analysis (hazard ratio = 2.01; 1.45-2.80; P < 0.001). Median survi...Continue Reading

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Citations

Jun 6, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alessandro CucchettiRita Golfieri
Apr 6, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Carlo SpositoVincenzo Mazzaferro
Jun 22, 2017·World Journal of Radiology·Giorgio GrecoCarlo Spreafico
Mar 2, 2016·World Journal of Experimental Medicine·Roberto MazzantiRenato Tassi
Jul 11, 2018·Future Oncology·Fabio MelchiorreGianpaolo Carrafiello
Oct 12, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenji Ikeda
Nov 12, 2016·World Journal of Gastroenterology : WJG·Hee Chul NamMyeong Jun Song
Jun 8, 2017·United European Gastroenterology Journal·Antonio FacciorussoGaetano Serviddio
Jan 30, 2018·World Journal of Gastroenterology : WJG·Antonio Facciorusso
Apr 29, 2016·World Journal of Gastroenterology : WJG·Antonio FacciorussoNicola Muscatiello
Nov 24, 2020·Therapeutic Advances in Medical Oncology·David PrinceJiansong Ji

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