Drug-eluting stents and balloons in peripheral arterial disease: evidence so far

International Journal of Clinical Practice
Y C Chan, S W Cheng

Abstract

Restenosis by myointimal hyperplasia after peripheral arterial angioplasty or stenting is a major problem limiting its long-term efficiency and patency, and may lead to recurrent symptoms. Drug-eluting devices which inhibit the proliferation of neo-intimal growth of vascular smooth muscle cells may prevent restenosis. The aim of this article is to examine the evidence in published literature on the use of drug-eluting devices in the treatment of peripheral arterial diseases. A systematic literature review was undertaken of all published literature on this subject using Medline and cross-referenced. All published relevant articles on the use of drug-eluting stents and balloons in peripheral arterial disease were used. Cochrane Central Register of Controlled Trials and electronic databases were also searched for on-going studies. Published results from randomised studies such as the SIROCCO I and II Trials and the THUNDER study, together with single cohort studies, are now available. There are on-going studies comparing drug-eluting and non-drug-eluting devices. Evidence from the published literature suggests that drug-eluting stents and balloons are safe and effective in preventing restenosis after peripheral angioplasty. Howeve...Continue Reading

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Citations

Oct 11, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Fabrizio FanelliFilippo Maria Salvatori
Apr 17, 2012·Nitric Oxide : Biology and Chemistry·Matthew J AlefBrian S Zuckerbraun
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Apr 23, 2013·Journal of Vascular Surgery·Stephen M SeedialK Craig Kent
Oct 26, 2016·Journal of Vascular Surgery·Rohun U PalekarSamuel A Wickline
Jul 14, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Lukasz TekieliPiotr Podolec
Nov 25, 2020·The Journal of Cardiovascular Surgery·Brian H LiStephen W Cheng

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