Drug-eluting stents: factors governing local pharmacokinetics

Advanced Drug Delivery Reviews
Chiming Yang, Helen M Burt

Abstract

Stent-based drug delivery system is a revolutionary approach to mitigate the negative affects of balloon angioplasty, improve immune responsiveness and prevent hyperplastic growth of smooth muscle in the restenotic state. Its success is therefore empirically associated with effective delivery of potent therapeutics to the target site at a therapeutic concentration, for a sufficient time, and in a biologically active form. However, local delivery with drug-eluting stents imparts large dynamic concentration gradients across tissues that can be difficult to identify, characterize and control. This review explores the factors such as physiological transport forces, drug physicochemical properties, local biological tissue properties and stent design that governs the local pharmacokinetics within the arterial wall by drug-eluting stent. Rational design and optimization of drug-eluting stents for local delivery thus requires a careful consideration of all these factors.

References

Jun 1, 1997·Journal of the American College of Cardiology·M A LovichE R Edelman
Mar 6, 1998·Nature Biotechnology·E R Edelman, M Lovich
Aug 3, 1999·Journal of Pharmaceutical Sciences·W K WanE R Edelman
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M A Lovich, E R Edelman
Apr 29, 2000·Circulation Research·C J CreelE R Edelman
Dec 18, 2001·Journal of Pharmaceutical Sciences·M A LovichE R Edelman
Apr 20, 2002·Circulation Research·Chao-Wei Hwang, Elazer R Edelman
Feb 11, 2003·Journal of Drug Targeting·Dmitri V SakharovDingeman C Rijken
Mar 8, 2003·International Journal of Cardiovascular Interventions·Chao-Wei HwangElazer R Edelman
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Andrew D LevinElazer R Edelman
Sep 15, 2004·International Journal of Pharmaceutics·John K JacksonHelen M Burt
Dec 29, 2004·Computer Methods in Biomechanics and Biomedical Engineering·D R HoseP V Lawford
Mar 30, 2005·Circulation·Chao-Wei HwangElazer R Edelman
May 28, 2005·Heart·A H Gershlick
Aug 17, 2005·Current Drug Targets. Cardiovascular & Haematological Disorders·N Swanson, A H Gershlick
Sep 27, 2005·Expert Review of Cardiovascular Therapy·Nicholas N KipshidzeJeffrey W Moses

❮ Previous
Next ❯

Citations

Mar 10, 2009·Annals of Biomedical Engineering·Mark ChenDean Ho
May 18, 2012·Molecular Pharmaceutics·Filippo RossiGiuseppe Perale
Mar 11, 2010·Biomedical Engineering Online·Barry M O'ConnellMichael T Walsh
Jan 24, 2008·PloS One·Margit FossDahong Zhang
Nov 12, 2013·Journal of Biomechanics·William J Denny, Michael T Walsh
Jan 29, 2014·TheScientificWorldJournal·Hongxia LiXicheng Wang
Jul 16, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kang Ju LeeWonHyoung Ryu
Oct 9, 2013·Biomechanics and Modeling in Mechanobiology·Barry M O'ConnellMichael T Walsh
Jan 8, 2016·Journal of the American Chemical Society·Mark W TibbittRobert Langer
Mar 1, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wahid KhanAbraham J Domb
Jan 18, 2011·International Journal of Pharmaceutics·Mario GrassiGabriele Grassi
Dec 5, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rachael W SirianniW Mark Saltzman
Nov 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Robert A CormackG Mike Makrigiorgos
Sep 19, 2008·Computational Biology and Chemistry·L DaviaM Grassi
Oct 16, 2007·Drug Discovery Today·Maggie A Z Hupcey, Sean Ekins
Jul 18, 2015·International Journal of Cardiology·Mi Seon JiUNKNOWN Korea Acute Myocardial Infarction Registry Investigators
Feb 2, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
May 26, 2012·Small·Chang Kuk ChoiWon Hyoung Ryu
Jun 21, 2015·Vascular Pharmacology·Austin I McDonald, M Luisa Iruela-Arispe
Jul 8, 2015·Therapeutic Delivery·Anne SeidlitzWerner Weitschies
Dec 4, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marika KamberiRichard J Rapoza
Jul 12, 2014·Mathematical Biosciences·Sean McGinty
Feb 27, 2010·Journal of Biomechanics·Giuseppe VairoFrancesco Migliavacca
Aug 9, 2016·Advanced Drug Delivery Reviews·Danir Fanisovich Bayramov, Jennifer Ann Neff
Sep 30, 2016·International Journal of Molecular Sciences·Lakshminath KundanatiNicola M Pugno
Apr 28, 2016·Journal of Biomedical Materials Research. Part a·Tayebeh ZohrabiLai Yeng Lee
Sep 28, 2017·Annals of Biomedical Engineering·Vaishnavi ChandrasekarBrendan J Casey
Aug 2, 2017·Tissue Engineering. Part C, Methods·David F Williams
Sep 20, 2015·Annals of Biomedical Engineering·C M McKittrickC McCormick
Jun 27, 2020·Computer Methods in Biomechanics and Biomedical Engineering· SarifuddinPrashanta Kumar Mandal
Oct 13, 2021·Drug Delivery and Translational Research·Ruyi ZhouYuqi Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Cardiovascular Interventions
Chao-Wei HwangE R Edelman
Journal of Controlled Release : Official Journal of the Controlled Release Society
Brinda BalakrishnanE R Edelman
© 2022 Meta ULC. All rights reserved