Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial

Lancet
Emmanouil S BrilakisDIVA Trial Investigators

Abstract

Few studies have examined the efficacy of drug-eluting stents (DES) for reducing aortocoronary saphenous vein bypass graft (SVG) failure compared with bare-metal stents (BMS) in patients undergoing stenting of de-novo SVG lesions. We assessed the risks and benefits of the use of DES versus BMS in de-novo SVG lesions. Patients were recruited to our double-blind, randomised controlled trial from 25 US Department of Veterans Affairs centres. Eligible participants were aged at least 18 years and had at least one significant de-novo SVG lesion (50-99% stenosis of a 2·25-4·5 mm diameter SVG) requiring percutaneous coronary intervention with intent to use embolic protection devices. Enrolled patients were randomly assigned, in a 1:1 ratio, by phone randomisation system to receive a DES or BMS. Randomisation was stratified by presence or absence of diabetes and number of target SVG lesions requiring percutaneous coronary intervention (one or two or more) within each participating site by use of an adaptive scheme intended to balance the two stent type groups on marginal totals for the stratification factors. Patients, referring physicians, study coordinators, and outcome assessors were masked to group allocation. The primary endpoint w...Continue Reading

Citations

Dec 21, 2018·Circulation. Cardiovascular Interventions·Nileshkumar J PatelDeepak L Bhatt
Dec 21, 2018·Circulation. Cardiovascular Interventions·Michael P Savage, David L Fischman
Feb 17, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Allison B Hall, Emmanouil S Brilakis
Nov 22, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Iosif XenogiannisEmmanouil S Brilakis
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Dec 24, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mark KheifetsLeor Perl
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Nov 7, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Iosif XenogiannisEmmanouil S Brilakis
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