Drug-eluting versus bare-metal stents in unprotected left main coronary artery stenosis a meta-analysis.

JACC. Cardiovascular Interventions
Sanjay B PandyaNirat Beohar

Abstract

We undertook a meta-analysis to assess outcomes for drug-eluting stents (DES) and bare-metal stents (BMS) in percutaneous coronary intervention for unprotected left main coronary artery (ULMCA) stenosis. Uncertainty exists regarding the relative performance of DES versus BMS in percutaneous coronary intervention for unprotected left main coronary stenosis. Of a total of 838 studies, 44 met inclusion criteria (n = 10,342). The co-primary end points were mortality, myocardial infarction (MI), target vessel/lesion revascularization (TVR/TLR), and major adverse cardiac events (MACE: mortality, MI, TVR/TLR). Event rates for DES and BMS were calculated at 6 to 12 months, at 2 years, and at 3 years. Crude event rates at 3 years were mortality (8.8% and 12.7%), MI (4.0% and 3.4%), TVR/TLR (8.0% and 16.4%), and MACE (21.4% and 31.6%). Nine studies were included in a comparative analysis (n = 5,081). At 6 to 12 months the adjusted odds ratio (OR) for DES versus BMS were: mortality 0.94 (95% confidence interval [CI]: 0.06 to 15.48; p = 0.97), MI 0.64 (95% CI: 0.19 to 2.17; p = 0.47), TVR/TLR 0.10 (95% CI: 0.01 to 0.84; p = 0.01), and MACE 0.34 (95% CI: 0.15 to 0.78; p = 0.01). At 2 years, the OR for DES versus BMS were: mortality 0.42 (95...Continue Reading

References

Feb 14, 1998·BMJ : British Medical Journal·M EggerG Davey Smith
May 12, 2000·Journal of the American College of Cardiology·M SilvestriB Comet
Jul 31, 2003·The American Journal of Cardiology·Chourmouzios A ArampatzisPatrick W Serruys
Aug 21, 2003·European Heart Journal·Michael P KelleyRobert L Wilensky
Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Sep 25, 2004·American Heart Journal·Jose Suarez de LezoJuan Herrador
Jun 10, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Frances WoodTift Mann
Aug 12, 2005·International Journal of Cardiovascular Interventions·Didier CarriéJacques Puel
Sep 13, 2005·Cardiology·Sang Hak LeeUNKNOWN Korean Multicenter Angioplasty Team (KOMATE) Investigators
Feb 21, 2006·Journal of the American College of Cardiology·Matthew J PricePaul S Teirstein
Jul 4, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Angela MiglioriniDavid Antoniucci
Nov 3, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Henry W HuangRichard E Shaw
Dec 30, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Marcelo SanmartinAndrés Iñiguez
May 10, 2007·JAMA : the Journal of the American Medical Association·Nirat BeoharDavid O Williams
May 29, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Cheng-I ChengYuan-Kai Hsieh
Jun 19, 2007·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Peter BarlisDavid J Clark
Sep 11, 2007·The American Journal of Cardiology·Marcelo SanmartínAndrés Iñiguez
Dec 18, 2007·International Journal of Cardiology·Ryan G SchraleA P Banning
Feb 2, 2008·Journal of the American College of Cardiology·Pawel E BuszmanMichal Tendera
Mar 1, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Frances O WoodJ Tift Mann
Mar 11, 2008·The American Journal of Cardiology·Young-Hak KimRoxana Mehran

❮ Previous
Next ❯

Citations

Jul 6, 2011·Current Cardiology Reports·David E Kandzari, John A Ormiston
Dec 3, 2011·Current Treatment Options in Cardiovascular Medicine·Seung-Jung Park, Duk-Woo Park
Jan 1, 2012·Cardiovascular Intervention and Therapeutics·Seung-Jung Park, Duk-Woo Park
Apr 6, 2011·The New England Journal of Medicine·Seung-Jung ParkKi Bae Seung
Mar 19, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Seung-Jung Park, Duk-Woo Park
Oct 5, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Pedro A LemosFabio B Jatene
Sep 29, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Giuseppe FerrantePatrick W Serruys
Sep 28, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Akihiro NomuraMasakiyo Nobuyoshi
Jan 24, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Tadayuki YakushijiMasahiko Ochiai
Aug 18, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Deng-Feng GengJing-Feng Wang
Feb 14, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mohammed AliDavid P Foley
Jul 28, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michael S LeeDavid E Kandzari
Feb 24, 2015·Current Cardiology Reports·Ralf E Harskamp, Duk-Woo Park
Apr 9, 2011·International Journal of Cardiology·George HahalisDimitrios Alexopoulos
Mar 15, 2015·Current Problems in Cardiology·Michael Ragosta
May 28, 2016·Cardiovascular Intervention and Therapeutics·Tomoyuki TakuraShinsuke Nanto
Aug 12, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hisato TakagiUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
Sep 4, 2012·Current Opinion in Cardiology·Ruben L J OsnabruggeA Pieter Kappetein
Oct 24, 2014·Expert Review of Cardiovascular Therapy·Chiara Bernelli
Jun 30, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Barry F UretskyAbdul Hakeem
Aug 7, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Fabrizio D'AscenzoGaetano M De Ferrari
Mar 13, 2021·European Cardiology·George William HunterDerek Connolly
Mar 21, 2020·International Journal of Cardiology·Julian YeohUNKNOWN Melbourne Interventional Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved