Drug-gut microbiota interactions: implications for neuropharmacology

British Journal of Pharmacology
Jacinta WalshNiall P Hyland

Abstract

The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the effects that drugs can have on the function and composition of the gut microbiome. Both microbiota-mediated alterations in drug metabolism and drug-mediated alterations in the gut microbiome can have beneficial or detrimental effects on the host. Greater insights into the mechanisms driving these reciprocal drug-gut microbiota interactions are needed to guide the development of microbiome-targeted dietary or pharmacological interventions, which may have the potential to enhance drug efficacy or reduce drug side effects. In this review, we explore the relationship between drugs and the gut microbiome, with a specific focus on potential mechanisms underpinning the drug-mediated alterations on the gut microbiome and the potential implications for psychoactive drugs. LINKED ARTICLES: This article is part of a themed section on When Pharmacology Meets the Microbiome: New Targets for Therapeutics? To view the other articles in this section visit http://onlinelibrary.wi...Continue Reading

References

Dec 15, 1979·Biochemical Pharmacology·R L KochP Goldman
Jan 1, 1992·European Journal of Clinical Pharmacology·R A van HogezandJ H van Tongeren
Sep 1, 1985·Antimicrobial Agents and Chemotherapy·C A BodetD J Drutz
May 1, 1973·The Journal of Pharmacy and Pharmacology·J Caldwell, G M Hawksworth
Nov 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G W Elmer, R P Remmel
Jul 1, 1994·European Journal of Drug Metabolism and Pharmacokinetics·M Mikov
May 1, 1996·The Journal of Antimicrobial Chemotherapy·J L Muñoz-BellidoJ A García-Rodríguez
Oct 6, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F RafiiC E Cerniglia
Apr 25, 2000·International Journal of Antimicrobial Agents·J L Munoz-BellidoJ A Garcìa-Rodrìguez
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Johan D SöderholmMary H Perdue
Feb 19, 2003·FEMS Immunology and Medical Microbiology·Cornelia Lass-FlörlReinhard Würzner
Aug 14, 2003·Experimental Gerontology·Klaus Turnheim
Jul 29, 2005·Critical Reviews in Food Science and Nutrition·Shantha L Kosaraju
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Mohammad S AlavijehAlan M Palmer
Jul 5, 2006·EMBO Reports·Ann M O'Hara, Fergus Shanahan
Aug 3, 2006·Pediatrics·John PendersEllen E Stobberingh
Aug 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Scott WeichMichael King
Sep 10, 2008·European Journal of Drug Metabolism and Pharmacokinetics·Hani Al-SalamiMomir Mikov
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·T Andrew ClaytonJeremy K Nicholson
Sep 11, 2009·PloS One·Britta BjörkholmSven Pettersson
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Karine GlouxJoël Doré
Dec 30, 2010·Current Drug Metabolism·Teruko Imai, Kayoko Ohura
Feb 2, 2011·Antimicrobial Agents and Chemotherapy·L Caetano M AntunesB Brett Finlay
Mar 3, 2011·MBio·Sandrine P ClausJeremy K Nicholson
May 20, 2011·Medical Hypotheses·Sydney M Finegold
Jan 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Graziano OnderUNKNOWN SHELTER Project
Feb 22, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hee Ji LeeJ Paul Fawcett
Mar 1, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rosa Krajmalnik-BrownJohn K DiBaise
Jul 17, 2012·Nature·Marcus J ClaessonPaul W O'Toole
Aug 21, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Henry J Haiser, Peter J Turnbaugh
Jan 22, 2013·Cell·Corinne Ferrier MauricePeter James Turnbaugh
Feb 6, 2013·Gastroenterology·Purna C KashyapJustin L Sonnenburg

❮ Previous
Next ❯

Citations

Nov 28, 2018·British Journal of Pharmacology·Niall P Hyland, John F Cryan
Feb 27, 2019·Psychopharmacology·Sofia CussottoJohn F Cryan
Mar 25, 2019·Hypertension·Hendrik BartolomaeusDominik N Muller
Nov 30, 2019·The Psychiatric Quarterly·Mary V Seeman
Jan 9, 2020·Harvard Review of Psychiatry·Thomaz F S BastiaanssenJohn F Cryan
May 31, 2019·Journal of the International AIDS Society·Salim S Abdool KarimBrent L Williams
Aug 28, 2020·Frontiers in Pharmacology·Damian Maseda, Emanuela Ricciotti
Dec 11, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maja ĐanićMomir Mikov
Feb 2, 2021·Gut Microbes·Laura E McCoubreyAbdul W Basit
Feb 22, 2021·Advanced Drug Delivery Reviews·Zahari VinarovPatrick Augustijns
Apr 6, 2021·EBioMedicine·Sofia CussottoBrendan T Griffin
Jun 12, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laura BeckmannWalter Raasch
Jun 19, 2021·Journal of Pharmacological and Toxicological Methods·Andrew A BieberichLaszlo Urban
Aug 14, 2021·Acta Pharmaceutica Sinica. B·Xintong ZhangZhonggao Gao
Apr 23, 2020·Journal of the American Society for Mass Spectrometry·Zikai HaoDaniel Figeys
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Treatment and Research
Meredith A J HullarJohanna W Lampe
Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Lenka JourovaEva Anzenbacherova
Progress in Neuro-psychopharmacology & Biological Psychiatry
W Kalow
Seminars in Liver Disease
Gobind AnandRohit Loomba
© 2022 Meta ULC. All rights reserved