PMID: 16508598Mar 2, 2006Paper

Drug hypersensitivity syndrome associated with a primary HHV6 infection

Annales de dermatologie et de vénéréologie
S DebarbieuxA Claudy

Abstract

Drug hypersensitivity syndrome is a severe life-threatening drug reaction. An association between this syndrome and HHV6 reactivation has been hypothesized. A 45 year-old women was treated with sulfasalazine for polyarthralgia. One month after beginning the treatment, she developed a drug hypersensitivity syndrome with severe acute hepatic failure. HHV6 serology and serum PCR revealed a primary HHV6 infection. We report the second case of drug hypersensitivity syndrome associated with a primary HHV6 infection. An immunological disorder may explain such an association by increasing viral replication. Detection and titration of anti-HHV6 antibodies in each case of drug hypersensitivity syndrome should help to confirm this association and possibly modify treatment strategy.

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Citations

Apr 14, 2007·Dermatologic Clinics·Joerg AlbrechtWarren Piette

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