Drug hypersensitivity

Acta Clinica Belgica
N Yawalkar

Abstract

Drug hypersensitivity represents an immune-mediated reaction to a drug. Although several drug hypersensitivity reactions are confined to the skin and rather mild, some may be life threatening and also involve further organs such as liver, kidney and bone marrow. The exact pathogenesis of many drug hypersensitivity reactions is still obscure. In this review the concepts on how small molecular drugs can activate the immune system are discussed and the hapten, prohapten and p-i concept are explained. Furthermore, the classification of drug hypersensitivity reactions and some common and severe clinical manifestations of drug-induced T cell mediated reactions are presented.

References

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Citations

May 13, 2011·Clinical Pharmacology and Therapeutics·M PirmohamedN H Shear
Aug 12, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Milo GattiEmanuel Raschi
Aug 26, 2010·Current Opinion in Allergy and Clinical Immunology

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