Drug-in-mucoadhesive type film for ocular anti-inflammatory potential of amlodipine: Effect of sulphobutyl-ether-beta-cyclodextrin on permeation and molecular docking characterization

Colloids and Surfaces. B, Biointerfaces
Ashirbad NandaSubrata Mallick

Abstract

Mucoadhesive type ocular film has been prepared for studying the anti-inflammatory potential of amlodipine (AML) on carrageenan-induced rabbit model and the effect of sulphobutyl-ether-beta-cyclodextrin on corneal permeation was tested. Hydroxypropyl methylcellulose (HPMC) ocular film was prepared after complexation of amlodipine with β-cyclodextrin, (BCD), hydroxypropyl β-cyclodextrin (HPCD), and sulfobutylether β-cyclodextrin (SBCD). The film without cyclodextrin showed a maximum swelling, and erosion to the highest extent. Both drug release and permeation were highly diffusion controlled and highest improvement was observed with SBCD due to increased dissolution, compared to other formulations with or without cyclodextrin. Highest binding energy and highest extent of amorphization were noticed in the SBCD film formulation. Improved amlodipine release in-vitro and ocular permeation were found by the HPMC film formulation after complexation of the drug with cyclodextrins wherein SBCD exhibited both to the highest extent. Binary and ternary systems molecular docking studies confirmed the lowest energy of binding between amlodipine and BCD compared to HBCD and SBCD. Signs of acute inflammation were mitigated within 2 h of film a...Continue Reading

Citations

Feb 6, 2019·International Journal of Molecular Sciences·Simone Braga CarneiroÁdley Antonini Neves de Lima
Oct 21, 2020·Journal of Drug Delivery Science and Technology·Juliana Rincón-LópezYareli Rojas-Aguirre
Jan 15, 2021·Advances in Colloid and Interface Science·Brunella GrassiriAndreas Bernkop-Schnürch
Mar 30, 2021·International Journal of Pharmaceutics·Helen Haixia WuBlech Michaela
Mar 16, 2021·AAPS PharmSciTech·Olivia L LanierAnuj Chauhan
May 16, 2021·International Journal of Pharmaceutics·Blanca Lorenzo-VeigaHakon Hrafn Sigurdsson
Aug 8, 2021·Materials·Melitini KoutsovitiMarilena Vlachou
Nov 28, 2021·Pharmaceuticals·Bharti GuptaAbdelwahab Omri

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