Drug-induced anaphylaxis: seven-year single-center survey

European Annals of Allergy and Clinical Immunology
Inês MotaMário Morais-Almeida

Abstract

Background and Objective. Drug-induced anaphylaxis (DIA) is the most common cause of fatal anaphylaxis. We aimed to characterize patients with DIA and their allergological workup. Methods. Systematic review of patients with history of DIA referred to our center over 7 years. Results. Included 125 patients (10% pediatric age), being 36 years the median age of first episode (from 1 to 74 years). The main culprits were nonsteroidal anti-inflammatory drugs (NSAIDs) (43%), antibiotics (42%) and anesthetic agents (6%). In 24% the reactions occurred in hospital setting and 14% perioperative. The etiology was confirmed in 75% through allergological workup. Conclusions. NSAIDs and antibiotics were responsible for most of DIA. The heterogeneity of mechanisms, the severity of the reactions and the lack of standardized in vivo and/or in vitro tests for some drugs do not allow to confirm the diagnosis in all cases. Patients with DIA should be evaluated in specialized centers to perform accurate diagnosis, to prevent recurrence and to find safe alternatives.

Citations

Sep 27, 2019·Allergy·Cristobalina MayorgaMaría José Torres
Aug 31, 2019·Allergy·Inmaculada DoñaJosé Antonio Cornejo-García
Mar 14, 2020·Expert Opinion on Drug Safety·Diogo MendesFrancisco Batel Marques
Jun 19, 2018·International Archives of Allergy and Immunology·Inês MotaMário Morais-Almeida
Mar 29, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ângela GasparUNKNOWN Portuguese Society of Allergology and Clinical Immunology (SPAIC) Anaphylaxis Interest Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Y Miura
BMJ : British Medical Journal
Richard O Day, Garry G Graham
Current Pharmaceutical Design
Marcel Bergmann, Jean-Christoph Caubet
© 2022 Meta ULC. All rights reserved