Drug-induced aortitis of the subclavian artery caused by pegfilgrastim: a case report.

Surgical Case Reports
Hikari JimboMitsue Saito

Abstract

Pegfilgrastim is a modified version of granulocyte-colony stimulating factor (G-CSF), with a polyethylene glycol (PEG) that prolongs its half-life in peripheral blood. It is prophylactically administered during chemotherapy to prevent severe febrile neutropenia. G-CSF-related aortitis is a rare side effect but reports of this disease have been increasing in recent years, probably due to PEGylation. Herein, we report a case who developed pegfilgrastim-induced aortitis, localized to the right subclavian artery, during adjuvant chemotherapy. Her condition recovered without the use of steroids. A 58-year-old woman was diagnosed with invasive ductal carcinoma of the left breast. She had a medical history of contralateral breast cancer and pyelonephritis. Following curative surgery for her left breast cancer, she received adjuvant chemotherapy. Two days after the first course of dose-dense paclitaxel, pegfilgrastim was used as planned. Eight days after the administration of pegfilgrastim, she developed a high fever of 38 °C and visited the emergency outpatient clinic 3 days after. Blood tests revealed an increased inflammatory response, and contrast-enhanced computed tomography (CT) revealed a wall thickening of the subclavian artery...Continue Reading

References

Mar 3, 2004·La Revue de médecine interne·C DarieA Grand
Nov 6, 2009·Clinical Drug Investigation·Giridhar U AdigaStefan Madajewicz
May 27, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yuki SatoKeisuke Tomii
Oct 22, 2018·Taiwanese Journal of Obstetrics & Gynecology·Kengo HiranumaYasuhisa Terao
Apr 9, 2019·Autoimmunity Reviews·Ioannis ParodisOscar P B Wiklander

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