Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7

PLoS Neglected Tropical Diseases
Natalie ReimersGabriele Schramm

Abstract

Schistosomiasis is a serious health problem especially in developing countries and affects more than 243 million people. Only few anthelmintic drugs are available up to now. A major obstacle for drug treatment is the different developmental stages and the varying host compartments during worm development. Anthelmintic drugs have been tested mainly on adult schistosomes or freshly transformed cercariae. Knowledge concerning the larval stages is lacking. In this study, we used in vitro-grown schistosomula (aged between 2 to 14 days) to investigate drug effects of the three anthelmintics praziquantel, artemether, and oxamniquine. Further, we analyzed the antibody accessibility of two exemplary schistosome antigens SmCD59a and SmKK7, before and after drug treatment. Our results demonstrated that praziquantel applied at a concentration of 1 μM inhibited development of all life stages. Application of 10 μM praziquantel led to dramatic morphological changes of all schistosomula. Artemether at 1 and 10 μM had differential effects depending on whether it was applied to 2-day as compared to 7- and 14-day schistosomula. While 2-day schistosomula were not killed but inhibited from further development, severe morphological damage was seen i...Continue Reading

References

Feb 1, 1977·Experimental Parasitology·P M KnopfJ A Reasoner
Jan 1, 1991·Revista Do Instituto De Medicina Tropical De São Paulo·P M CoelhoS E Gerken
Jan 1, 1987·The Journal of Antimicrobial Chemotherapy·T K Daneshmend, M A Homeida
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·R F SturrockT K arap Siongok
Dec 1, 1985·Experimental Parasitology·A A SabahM J Doenhoff
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J J LearyD C Ward
Jan 1, 1982·Immunological Reviews·A CapronG Torpier
Nov 15, 2000·Parasitology International·J KhalifeM Capron
Mar 20, 2001·Molecular and Biochemical Parasitology·M M ChenD J Sullivan
Apr 19, 2002·The New England Journal of Medicine·Allen G P RossDonald P McManus
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·Jürg UtzingerBurton H Singer
Jan 1, 1991·Parasitology Today·M J DoenhoffD J McLaren
Jul 20, 2005·Brazilian Journal of Biology = Revista Brasleira De Biologia·T I B BrunoJ F Carvalho
Sep 1, 2009·Trends in Parasitology·R Alan Wilson, Patricia S Coulson
Sep 23, 2009·The Journal of Experimental Medicine·Rick M MaizelsThomas A Wynn
Mar 31, 2010·PLoS Neglected Tropical Diseases·Carla L BlackDaniel G Colley
May 24, 2011·The Journal of Antimicrobial Chemotherapy·Jennifer KeiserMireille Vargas
Aug 11, 2011·PLoS Pathogens·Mark S WilsonThomas A Wynn
Sep 14, 2011·PLoS Neglected Tropical Diseases·Sophia J Parker-ManuelR Alan Wilson
Oct 2, 2012·Molecular and Biochemical Parasitology·Jarrett Hines-KayCharles Cunningham
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Anthony Danso-AppiahJürg Utzinger
Jun 19, 2013·Journal of Infection in Developing Countries·Solomon M AbayAbiy Habtewold
Jul 3, 2013·Angewandte Chemie·Sophie A-L Thétiot-LaurentBernard Meunier
Jul 17, 2013·Immunology and Cell Biology·Hamish E G McWilliamEls N T Meeusen
Nov 10, 2013·PLoS Neglected Tropical Diseases·Leonardo P FariasLuciana C C Leite

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Citations

Sep 22, 2018·Parasite Immunology·Moses EgesaStephen Cose
Jan 29, 2019·PLoS Neglected Tropical Diseases·Sören FrahmClarissa Prazeres da Costa
Feb 19, 2020·Phytotherapy Research : PTR·Muhammad Torequl IslamJavad Sharifi-Rad
May 11, 2021·Frontiers in Immunology· AnisuzzamanClarissa Prazeres da Costa
Jun 8, 2021·Trends in Parasitology·Mostafa Zamanian, John D Chan

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Methods Mentioned

BETA
FCS
fluorescence microscopy
confocal microscopy
sulfotransferase
confocal microsocopy

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