Drug-Induced Glucocorticoids and Memory for Substance Use

Trends in Neurosciences
Elizabeth V Goldfarb, Rajita Sinha

Abstract

The biological stress response of the body forms one of the foundations of adaptive behavior, including promoting (and impairing) different forms of memory. This response transcends stressful experiences and underlies reactions to challenges and even reinforcers such as addictive substances. Nevertheless, drug-induced stress responses are rarely incorporated into models of addiction. We propose here that drug-induced stress responses (particularly glucocorticoids) play a crucial role in addictive behavior by modulating the formation of memories for substance-use experiences. We review the contributions of amygdala-, striatum-, and hippocampus-based memory systems to addiction, and reveal common effects of addictive drugs and acute stress on these different memories. We suggest that the contributions of drug-induced stress responses to memory may provide insights into the mechanisms driving addictive behavior.

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Citations

Jan 3, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aaron M Bornstein, Hanna Pickard
Mar 4, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elizabeth V GoldfarbRajita Sinha
Jun 27, 2020·Brain Sciences·Anna GrzywaczBlazej Rubiś
Dec 9, 2020·British Journal of Clinical Pharmacology·E H Baker

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