Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians

Journal of Transplantation
Muhammad Abdul Mabood KhalilJackson Tan

Abstract

Drug-induced hematological cytopenia is common in kidney transplantation. Various cytopenia including leucopenia (neutropenia), thrombocytopenia, and anemia can occur in kidney transplant recipients. Persistent severe leucopenia or neutropenia can lead to opportunistic infections of various etiologies. On the contrary, reducing or stopping immunosuppressive medications in these events can provoke a rejection. Transplant clinicians are often faced with the delicate dilemma of balancing cytopenia and rejection from adjustments of immunosuppressive regimen. Differentials of drug-induced cytopenia are wide. Identification of culprit medication and subsequent modification is also challenging. In this review, we will discuss individual drug implicated in causing cytopenia and correlate it with corresponding literature evidence.

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Citations

Apr 1, 2020·World Journal of Transplantation·Fedaey AbbasAhmed Halawa
Nov 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jolanta MalyszkoJacek Malyszko
Jun 24, 2021·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Amanda VinsonKarthik Tennankore
Sep 9, 2021·Pediatric Transplantation·Chaowapong JarasvaraparnSakil Kulkarni

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Methods Mentioned

BETA
genotyping
biopsy

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