PMID: 15898831May 19, 2005Paper

Drug-induced hypersensitivity: role in drug development

Toxicological Reviews
Helen V Ratajczak

Abstract

Drug-induced hypersensitivity is an adverse reaction, characterised by damaging immune-mediated responses, initiated by medicine given at therapeutic doses for prevention, diagnosis or treatment. Immune-mediated drug hypersensitivity accounts for 6-10% of the adverse drug reactions, which rank between the fourth and sixth leading causes of death in the US. With <10% of all adverse drug reactions reported, the magnitude of the problem is significant, with estimates of costs >$US30 billion annually in the US (1995 value). In addition, the costs of not determining the potential of a drug to produce hypersensitivity in the pre-clinical phase of drug development can be substantial. It has been estimated that the pre-clinical phase and clinical phase I, phase II and phase III costs are approximately $US6 million, $US12 million, $US12 million and $US100 million per drug, respectively (1999 values). It is important that investigational drugs with the potential to produce hypersensitivity reactions be identified as early in the development process as possible. Some adverse reactions to drugs can be avoided if drug-drug interactions are known or if there is a structure-activity relationship established. However, these methods are inadequ...Continue Reading

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Citations

Jul 27, 2006·Expert Opinion on Drug Metabolism & Toxicology·Jacques Descotes
Mar 12, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Carolina Miranda de Sousa LimaJocivânia Oliveira da Silva

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