PMID: 15898831May 19, 2005Paper

Drug-induced hypersensitivity: role in drug development

Toxicological Reviews
Helen V Ratajczak


Drug-induced hypersensitivity is an adverse reaction, characterised by damaging immune-mediated responses, initiated by medicine given at therapeutic doses for prevention, diagnosis or treatment. Immune-mediated drug hypersensitivity accounts for 6-10% of the adverse drug reactions, which rank between the fourth and sixth leading causes of death in the US. With <10% of all adverse drug reactions reported, the magnitude of the problem is significant, with estimates of costs >$US30 billion annually in the US (1995 value). In addition, the costs of not determining the potential of a drug to produce hypersensitivity in the pre-clinical phase of drug development can be substantial. It has been estimated that the pre-clinical phase and clinical phase I, phase II and phase III costs are approximately $US6 million, $US12 million, $US12 million and $US100 million per drug, respectively (1999 values). It is important that investigational drugs with the potential to produce hypersensitivity reactions be identified as early in the development process as possible. Some adverse reactions to drugs can be avoided if drug-drug interactions are known or if there is a structure-activity relationship established. However, these methods are inadequ...Continue Reading


Jan 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K Sarlo, E D Clark
Apr 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·H V RatajczakP T Thomas
Oct 1, 1991·Regulatory Toxicology and Pharmacology : RTP·G Zbinden
May 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·C GradleP Thomas
Nov 1, 1986·Gut·E G BreenF M Stevens
Mar 1, 1969·The Journal of Investigative Dermatology·B Magnusson, A M Kligman
Feb 1, 1982·Anesthesiology·C E RosowJ J Savarese
Sep 1, 1980·Critical Reviews in Toxicology·S AhlstedtB Ortengren
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H J ZimmermanW C Maddrey
Nov 1, 1980·The American Review of Respiratory Disease·H V RatajczakH B Richerson
Dec 14, 1995·The New England Journal of Medicine·J C RoujeauF Locati
Sep 11, 1995·Archives of Internal Medicine·S F KempP Lieberman
Feb 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T T KawabataF M Graziano
Sep 22, 1994·Toxicology·F VerdierJ Descotes
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·H L RitzK Sarlo
Aug 1, 1996·Toxicology Letters·I KimberR J Dearman
Sep 1, 1996·Toxicology and Applied Pharmacology·R AlbersR Pieters
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D A BasketterM D Barratt
Apr 1, 1997·Toxicology and Applied Pharmacology·S M FurstA J Gandolfi
Jul 1, 1997·The Journal of Clinical Investigation·B SchnyderW J Pichler
Sep 26, 1997·International Archives of Allergy and Immunology·S M Furst, A J Gandolfi
Apr 16, 1998·Immunology Today·P GriemE Gleichmann
Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Apr 29, 1998·JAMA : the Journal of the American Medical Association·D W Bates
Oct 7, 1998·Chemical Research in Toxicology·B K ParkN R Kitteringham
Dec 5, 1998·Seminars in Immunology·P Matzinger
Mar 10, 1999·JAMA : the Journal of the American Medical Association·T Brewer, G A Colditz
May 18, 1999·JAMA : the Journal of the American Medical Association·M A FriedmanL J Thompson
Dec 14, 1999·British Journal of Clinical Pharmacology·L NaldiR Leone
Feb 9, 2000·Immunopharmacology·J F Regal, A Klos
Oct 13, 2000·Regulatory Toxicology and Pharmacology : RTP·H OlsonA Heller
Jan 6, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D J NaisbittB K Park
Jan 9, 2001·Archives of Internal Medicine·A I NeugutR L Miller
Feb 13, 2001·Toxicology·D WierdaC M Zwickl
Mar 10, 2001·JAMA : the Journal of the American Medical Association·J P Ioannidis, J Lau

❮ Previous
Next ❯


Jul 27, 2006·Expert Opinion on Drug Metabolism & Toxicology·Jacques Descotes
Mar 12, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Carolina Miranda de Sousa LimaJocivânia Oliveira da Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

© 2021 Meta ULC. All rights reserved