Drug-induced inflammatory bowel disease and IBD-like conditions

Inflammatory Bowel Diseases
Marie-France DubeauRemo Panaccione

Abstract

The pathogenesis of inflammatory bowel disease (IBD) is multifactorial and results from an interaction between genetic, immunologic, microbial, and environmental factors. Certain drugs could act as a trigger for the disease and have been implicated in the development of new onset IBD in a number a studies. These relationships are based on case reports and cohort studies, as proving this in the context of randomized controlled trials would be difficult. Drugs that have been linked to causing or worsening IBD include isotretinoin, antibiotics, nonsteroidal antiinflammatory drugs, oral contraceptives, mycophenolate mofetil, etanercept, ipilimumab, and rituximab. Bowel preparation for colonoscopy has also been associated with aphthoid lesions that may be confused with IBD. However, given the source of these reports we have to be cautious in the interpretation of the data before concluding that these drugs trigger IBD and what is being observed is not related to other confounding factors. Different pathogenic mechanisms have been suggested for the different drugs listed above. In order to clarify the confusion a comprehensive literature review was performed with the goal of advancing the knowledge on this subject.

References

Aug 1, 1991·Digestive Diseases and Sciences·A J WakefieldR E Pounder
May 1, 1986·Journal of the American Academy of Dermatology·M B Brodin
Sep 1, 1987·Gastroenterology·P MartinJ M Blakeman
Oct 1, 1987·Scandinavian Journal of Gastroenterology·T GilatM J Langman
Jan 1, 1983·Dermatologica·P D PigattoA F Finzi
Apr 1, 1982·Journal of the American Academy of Dermatology·C CamisaG Weissmann
Mar 1, 1994·Digestive Diseases and Sciences·J I WurzelmannR S Sandler
Jan 1, 1993·Springer Seminars in Immunopathology·A C Allison, E M Eugui
Dec 1, 1995·Clinical and Experimental Immunology·R DuchmannK H Meyer zum Büschenfelde
Mar 1, 1996·Journal of the American Academy of Dermatology·J M GeigerJ H Saurat
May 1, 1996·Gastrointestinal Endoscopy·F R ZwasR N Eisen
May 20, 1998·Inflammatory Bowel Diseases·M Lebwohl, O Lebwohl
May 8, 1999·The American Journal of Clinical Nutrition·R I MackieH R Gaskins
Jan 22, 2000·Arthritis and Rheumatism·L J CroffordL B van de Putte
Jan 29, 2000·Alimentary Pharmacology & Therapeutics·K FellermannE F Stange
Apr 28, 2000·International Immunology·E MizoguchiA K Bhan
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D M Rennick, M M Fort
Jul 6, 2000·Immunopharmacology·A C Allison, E M Eugui
Aug 19, 2000·The American Journal of Gastroenterology·J B FelderG Gleim
Feb 24, 2001·Scandinavian Journal of Gastroenterology·J M ZeehA U Dignass
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z LiuJ L Ceuppens
Aug 28, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M Behrend
Oct 26, 2001·The Annals of Pharmacotherapy·D E Reniers, J M Howard
Feb 13, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B SiciliaF Gomollón
Mar 22, 2002·Journal of the American Academy of Dermatology·Diane K WysowskiAmarilys Vega
Sep 5, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giovanna CipollaGianmario Frigo
Oct 31, 2002·Gastroenterology·Daniel J BergRichard G Lynch
Nov 15, 2002·Transplantation Proceedings·Y QuirozB Rodriguez-Iturbe
Jan 28, 2003·Therapeutic Drug Monitoring·Maria ShipkovaEberhard Wieland
Mar 19, 2003·Alimentary Pharmacology & Therapeutics·M H Gleeson, A J M Davis
Nov 15, 2003·International Journal of Surgical Pathology·John C PapadimitriouCinthia B Drachenberg
Jan 16, 2004·Gut·T CardJ G Wheeler
Feb 12, 2004·Alimentary Pharmacology & Therapeutics·H H WenzlW Petritsch

❮ Previous
Next ❯

Citations

Feb 7, 2013·Best Practice & Research. Clinical Gastroenterology·Bincy P Abraham, Joseph H Sellin
Jan 17, 2014·World Journal of Gastroenterology : WJG·Ian M Carroll, Nitsan Maharshak
Feb 22, 2016·Journal of the American Academy of Dermatology·Andrea L ZaengleinKevin M Boyer
Aug 22, 2015·Journal of Crohn's & Colitis·Vito AnneseUNKNOWN ECCO
Jun 17, 2015·Alimentary Pharmacology & Therapeutics·A GuptaS Khanna
May 18, 2016·European Journal of Gastroenterology & Hepatology·Ioannis V MitselosEpameinondas V Tsianos
Oct 18, 2016·Current Opinion in Ophthalmology·Akshay S Thomas, Phoebe Lin
Nov 28, 2017·Virchows Archiv : an International Journal of Pathology·Deepa T Patil, Robert D Odze
Feb 9, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Evangelia Legaki, Maria Gazouli
Feb 2, 2018·Journal of Medicinal Food·Michael RohrSampath Parthasarathy
Apr 29, 2015·Infection and Immunity·Nitsan MaharshakIan M Carroll
Feb 1, 2019·The Annals of Pharmacotherapy·Joshua A RadelSachin A Shah
Jul 5, 2017·Experimental and Therapeutic Medicine·Bin Wang, Cunbing Wu
Jun 20, 2017·Case Reports in Oncology·Reem AkelArafat Tfayli
Aug 22, 2020·World Journal of Gastroenterology : WJG·Yezaz A GhouriBo Shen
Aug 12, 2016·Turkish Journal of Medical Sciences·Duru Tabanlioğlu OnanRefika Ferda Artüz
Jul 12, 2020·Digestive Diseases and Sciences·Emilie H RegnerUma Mahadevan
Dec 8, 2020·Scandinavian Journal of Gastroenterology·Valdimar B KristjánssonEinar S Björnsson
Jun 23, 2021·Gastroenterología y hepatología·Gonzalo Hijos-MalladaFernando Gomollón
Aug 31, 2021·Therapeutics and Clinical Risk Management·Nayoung HanIn-Wha Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of the American Academy of Dermatology
Ali AlikhanGabriel F Sciallis
Journal of the American Academy of Dermatology
Mary E Maloney, Stephen P Stone
Archives of Dermatology
Catalin Mihai Popescu, Raluca Popescu
© 2021 Meta ULC. All rights reserved