Drug-induced inhibition of proteoglycanase activity in the Hulth-Telhag model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
K K IshizueH J Mankin

Abstract

Evidence has accumulated that there are increased degradative enzymes in osteoarthritis responsible for joint destruction. These enzymes are metal-dependent, and inhibited by EDTA. EDTA was administered intra-articularly to rabbits in an experimental model of osteoarthritis. There was a 25% reduction in neutral proteoglycanase activity and 75% of the animals had a reduction in the severity of the arthritis as measured on a histologic-histochemical grading system. It is suggested that future chemotherapeutic studies on arthritis might focus on enzyme inhibition.

References

Oct 1, 1976·The Journal of Clinical Investigation·A I SapolskyJ F Woessner
Feb 1, 1977·The Journal of Clinical Investigation·M G EhrlichG Vigliani
Sep 1, 1978·Arthritis and Rheumatism·M G EhrlichH J Mankin
Apr 1, 1978·The Biochemical Journal·M T Bayliss, S Y Ali
Mar 1, 1973·The Journal of Clinical Investigation·A I SapolskyD S Howell
Apr 12, 1973·Biochimica Et Biophysica Acta·R I MorrisonD Prior
Apr 1, 1974·The Journal of Clinical Investigation·A I SapolskyJ F Woessner
Jan 1, 1970·Acta Orthopaedica Scandinavica·A HulthH Telhag
Oct 1, 1962·Analytical Biochemistry·T BITTER, H M MUIR

❮ Previous
Next ❯

Citations

Jun 16, 2000·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·J F Burkholder
May 15, 1997·Microscopy Research and Technique·D L GardnerK Oates

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Scandinavian Journal of Rheumatology. Supplement
M H Liang
Annals of the Rheumatic Diseases
T E McAlindon, D T Felson
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
C RathakrishnanM L Tiku
British Journal of Industrial Medicine
J S LAWRENCE
© 2022 Meta ULC. All rights reserved