PMID: 22576392May 12, 2012Paper

Drug-induced interstitial pneumonitis due to low-dose lenalidomide

Internal Medicine
Kei KunimasaTadashi Ishida

Abstract

Lenalidomide is a second-generation immunomodulatory drug that has been approved to treat relapsed or refractory multiple myeloma. Here, we describe a patient who was treated with a low dose of lenalidomide (5 mg/day on days 1-21 of a 28-day cycle) because the standard dose of bortezomib was too toxic and adverse events persisted. However, he developed fever, dyspnea, hypoxia and pulmonary infiltrates. The results of an extensive workup for other causes including infections were negative and the final diagnosis was lenalidomide-induced interstitial pneumonitis. This is the first case report of lenalidomide-induced pneumonitis in a Japanese patient.

Citations

Apr 30, 2017·Respirology Case Reports·Andrew TomaAshutosh Sachdeva
Apr 11, 2018·Japanese Journal of Clinical Oncology·Toru TanakaAkihiko Gemma

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