Drug-induced Liver Injury: The Hepatic Pathologist's Approach

Gastroenterology Clinics of North America
David E Kleiner

Abstract

The evaluation of liver biopsies in suspected drug-induced liver injury (DILI) can be complex. The biopsy may be approached systematically, by identification of histologic lesions and then identification of the overall pattern of injury. Potential DILI must be separated from concomitant non-DILI liver disease. The findings can be analyzed with respect to the various prescription and nonprescription medications and dietary supplements under suspicion to provide a complete interpretation of the findings. The pathologic findings, the histologic differential diagnosis, and expert interpretation are part of a complete biopsy assessment and provide information that is of greatest value in patient management.

Citations

Nov 24, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Lan WangXinyan Zhao
May 1, 2019·MMW Fortschritte der Medizin·Andreas Benesic
Nov 26, 2019·Food Science & Nutrition·Guo-Kai WangJai-Sing Yang
Jul 9, 2020·Veterinary World·Chrismawan ArdiantoJunaidi Khotib
May 5, 2020·Hepatology Communications·Naemat Sandhu, Victor Navarro
Jan 5, 2021·Journal of Biochemical and Molecular Toxicology·Devaraj Ezhilarasan, Subramanian Raghunandhakumar
Sep 25, 2020·Reviews on Environmental Health·Velid Unsalİlhan Sabancilar

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