Abstract
Drug-induced lupus (DIL) includes a spectrum of drug-induced reactions often characterised by a clinical phenotype similar to that of idiopathic systemic lupus eruthematosus (SLE) but usually lacking major SLE complications. Different drugs may be associated with distinct clinical and serological profiles, and early recognition is crucial. Drugs traditionally associated with DIL include procainamide, hydralazine, quinidine and others, but strong associations with newer agents, such as TNF α (TNFα) inhibitors, are increasingly recognised. The pathogenic mechanisms explaining how drugs that have heterogeneous chemical structure and function lead to autoimmunity are only partially understood. However, it is likely that traditional DIL-associated agents can boost innate immune responses, particularly neutrophil responses, with neutrophil extracellular trap (NET) formation and exposure of autoantigens. Research in the field of DIL is evolving and may provide interesting models for the study of autoimmunity.
Citations
Jan 1, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Cristina SoléPere Ginès
Sep 1, 2020·AACN Advanced Critical Care·Erin K Gasser, Hildy M Schell-Chaple
Sep 3, 2020·JAMA Dermatology·Jeanette Halskou HaugaardAlexander Egeberg
Aug 11, 2019·Nature Reviews. Rheumatology·Joerg Wenzel
Aug 8, 2020·Modern Rheumatology Case Reports·Akitsu YoshidaMasayoshi Harigai
Nov 15, 2019·International Journal of Dermatology·Jeremy B FreedmanAndrea D Maderal
Nov 22, 2019·World Journal of Nephrology·Iacopo GianassiLino Calogero Cirami
Apr 17, 2020·Frontiers in Immunology·José M CarballidoMichael Kammüller
Jun 14, 2019·Proceedings·Maria Catalina EspinosaOnome Whiteru Ifoeze
Aug 28, 2020·Current Rheumatology Reports·Jay PatelVictoria P Werth
Sep 5, 2020·Nature Reviews. Rheumatology·David S Pisetsky, Peter E Lipsky
May 6, 2019·Cells·Akiko NagasuYoshitaka Morita
Jun 7, 2019·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Apr 6, 2019·Current Medicinal Chemistry·Qingjun PanHua-Feng Liu
Sep 26, 2020·Dermatologic Therapy·Rubén González-CuevasPablo Vargas-Mora
Nov 21, 2020·Expert Opinion on Biological Therapy·Ana Lorenzo-Vizcaya, David A Isenberg
Dec 23, 2020·Lupus·Eliana Figueredo ZamoraCourtney R Schadt
Dec 29, 2020·Rheumatology·Adrian Y S Lee, Tom P Gordon
Mar 31, 2021·International Journal of Pharmaceutics·Haruka TakataTatsuhiro Ishida
Jun 19, 2021·The Journal of International Medical Research·Xiaoli PanMei Tian
Sep 2, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Yasuhito Hamaguchi
Nov 18, 2020·Current Drug Metabolism·Milica S LalosevicMirjana Stojkovic
Dec 22, 2020·Indian Dermatology Online Journal·Ömer KutluHatice Meral Ekşioğlu
Aug 21, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Jaspreet Kaler, Gurjit S Kaeley
Jan 29, 2022·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sanjana SarangarajanBheemanathi Hanuman Srinivas