Drug-Induced Photosensitivity - a Continuing Diagnostic Challenge

Acta clinica Croatica
Liborija Lugović-MihićDiana Ćesić

Abstract

When taking different drugs, their possible side effects on the skin should be considered, including skin reactions connected to photosensitivity. This photosensitivity caused by drugs can appear as phototoxic reactions (which occur more often) or photoallergic reactions (which occur less often and include allergic mechanisms). The following drugs stand out as medications with a high photosensitivity potential: nonsteroidal anti-inflammatory drugs (NSAIDs), cardiovascular drugs (such as amiodarone), phenothiazines (especially chlorpromazine), retinoids, antibiotics (sulfonamides, tetracyclines, especially demeclocycline and quinolones), etc. In recent years, photosensitive reactions to newer drugs have appeared, e.g., targeted anticancer therapies such as BRAF kinase inhibitors (vemurafenib, dabrafenib), EGFR inhibitors, VEGFR inhibitors, MEK inhibitors, Bcr-Abl tyrosine kinase inhibitors, etc. In patients taking drugs over a longer period of time (e.g., NSAIDs, cardiovascular drugs, etc.), a particular problem arises when an unrecognized drug-induced photosensitivity on the skin manifests in summer months. When taking patient histories, the physician/dermatovenereologist should bear in mind that any drug the patient is current...Continue Reading

Citations

Jul 21, 2020·International Journal of Dermatology·Soufila KtTarun Narang
Jan 3, 2020·The Journal of Chemical Physics·Nikolay PolyakovTatyana Leshina
Jun 19, 2019·The Journal of Dermatological Treatment·Elena AraviiskaiaCarlo Pincelli
May 28, 2021·Methods and Applications in Fluorescence·Michael C LarsonJennifer K Barton

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