Drug-induced phototoxicity: A systematic review

Journal of the American Academy of Dermatology
Whan Ben KimSteven J Glassman

Abstract

Phototoxicity has been attributed to numerous oral drugs over the past 60 years. Determine the quality of evidence supporting suspected phototoxicity from oral drugs. The MEDLINE and EMBASE databases were searched for all studies that contain original data for drug-induced phototoxicity and were published between May 1959 and December 2016. Study quality was assessed by using a modified Grading of Recommendations, Assessment, Development and Evaluation scale. The review included 240 eligible studies with a total of 2466 subjects. There were 1134 cases of suspected phototoxicity associated with 129 drugs. Most associations were supported by either very low-quality or low-quality evidence (89.1% of the studies). Medications supported by stronger evidence were vemurafenib, nonsteroidal anti-inflammatory drugs, and antibiotics, specifically, fluoroquinolones and tetracyclines. The most frequently reported drugs were vemurafenib, voriconazole, doxycycline, hydrochlorothiazide, amiodarone, and chlorpromazine. Photobiologic evaluation was performed in only 56 studies (23.3%), whereas challenge-rechallenge was done in 10% of cases. Only English-language publications were reviewed. Cases of phototoxicity that had been incorrectly catego...Continue Reading

Citations

Oct 17, 2019·Photodermatology, Photoimmunology & Photomedicine·Markus V HepptMarkus Reinholz
Aug 28, 2019·American Journal of Clinical Dermatology·Nicola E NatsisAlice B Gottlieb
Jun 22, 2020·Photodermatology, Photoimmunology & Photomedicine·Amirah AlrashidiTashmeeta Ahad
Dec 14, 2018·Toxicology Research·Xiaoqi LiLisha You
Mar 20, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kim M BlakelyCheryl F Rosen
Jun 12, 2019·Pediatric Annals·M Denise Dowd
Sep 17, 2020·Allergy, Asthma & Immunology Research·Seung Hui SeokHyun Jung Kim
Apr 21, 2019·Photodermatology, Photoimmunology & Photomedicine·Ana DubónInmaculada Andreu
Jan 5, 2021·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H StegeC Hünefeld
Jan 26, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Georg Amun Hofmann, Benedikt Weber
Feb 13, 2021·Contact Dermatitis·Yixin ShaoHui Tang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdulilah Dawoud Bani-Yaseen
Mar 26, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·T PasseronJ Krutmann
May 6, 2021·Seizure : the Journal of the British Epilepsy Association·Maryam ShirzadiEylert Brodtkorb
May 16, 2021·Dermatologic Therapy·Giulia OdoriciVincenzo Bettoli
Aug 14, 2021·JAAD Case Reports·Alysha ColonMaria I Longo-Imedio

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