Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose

Substance Abuse Treatment, Prevention, and Policy
Davood SorooshOmid Mehrpour

Abstract

Iran is a country with the highest rate of opioid addiction in the world. The most commonly used opioid in Iran is opium, and methadone is in second place. The trend of drug use has changed from opium to methadone from 2006 to 2011. Presence of a large number of addicted people and methadone maintenance therapy clinics make methadone readily available in Iran. Therefore, evaluation of the epidemiological characteristic of methadone toxicity and its effects on the heart is essential. In This cross-sectional, retrospective, descriptive, analytical study all patients with methadone or opium toxicity who had been admitted to Vasei hospital, Sabzevar, Iran, during the years 2015 and 2016 were included, and their records were evaluated. Demographic data, addiction history, underlying diseases, and the outcome of admission were recorded. Then, corrected QT interval (QTc) of the first ECG of the patients after admission was evaluated. The Majority of toxicities occurred in those above 30 years of age (71.4%), who lived in cities (62.8%), and were married (69.2%). A positive history of addiction was considerably higher in the opium group (72.3% versus 43.3%). There was no significant difference regarding QTc prolongation between patient...Continue Reading

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Citations

Nov 20, 2019·Journal of Clinical Pharmacology·Munveer ThindJ Rick Turner
Apr 19, 2020·Substance Abuse Treatment, Prevention, and Policy·Samaneh NakhaeeOmid Mehrpour
Nov 21, 2020·Journal of Addictive Diseases·Bahadir DemirAbdurrahman Altindag
Apr 9, 2021·Peptides·Richard J Bodnar

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