Drug-Induced Restless Legs Syndrome

The Annals of Pharmacotherapy
Edna Patatanian, Melanie K Claborn

Abstract

To review the literature on drug-induced restless legs syndrome (DI-RLS). The review included a search for English-language literature from 1966 to December 2017 in the MEDLINE, PubMed, and Ovid databases using the following search terms: restless legs syndrome (RLS), periodic limb movement, adverse effects, and drug-induced. In addition, background articles on the pathophysiology, etiology, and epidemiology of RLS were retrieved. Bibliographies of relevant articles were reviewed for additional citations. All case reports, case series, and review articles of DI-RLS were identified and analyzed. There were only a small number of controlled clinical trials, and most data were from case reports and case series. Several drugs and drug classes have been implicated in DI-RLS, with antidepressants, antipsychotics, and antiepileptics having the most evidence. In addition, RLS may be linked with a number of disorders or underlying predisposing factors as well. The prevalence of RLS is variable and ranges from 3% to 19% in the general population. There are many predisposing factors to RLS, but an emerging body of evidence suggests that there is an association between numerous drugs and RLS.

References

Dec 1, 1991·Biological Psychiatry·T TeraoK Abe
Sep 1, 1986·The American Journal of Psychiatry·E M Heiman, M Christie
Oct 1, 1996·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J S Simpson
Oct 1, 1996·Journal of the Neurological Sciences·R Bakshi
May 19, 1998·Psychosomatics·R Hargrave, D J Beckley
Apr 29, 1999·International Clinical Psychopharmacology·J HoriguchiT Nishikawa
Oct 3, 1999·Journal of Clinical Psychopharmacology·T KrausT Pollmächer
Mar 21, 2000·Archives of Internal Medicine·S B Dimmitt, G J Riley
Apr 20, 2001·Sleep Medicine·R P. Allen, C J. Earley
Apr 16, 2002·Psychiatry and Clinical Neurosciences·Won-Myong BahkKwang-Soo Kim
Jul 11, 2002·Pharmacopsychiatry·T C WetterT Bronisch
Jan 15, 2003·Neurology·Judy T ChenBrian K Alldredge
Jan 18, 2003·The Journal of Clinical Psychiatry·Mehmed Yucel AğargünOmer Akil Ozer
May 23, 2003·The New England Journal of Medicine·Christopher J Earley
Nov 1, 2003·Sleep Medicine·Arthur S WaltersUNKNOWN International Restless Legs Syndrome Study Group
Jun 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Jeffrey S LaRochelle, Barbara I Karp
Sep 21, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Eng-King TanRatnagopal Pavanni
Oct 4, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Roberto VetrugnoPasquale Montagna
Nov 12, 2005·Journal of Clinical Psychopharmacology·Narsimha Reddy PinnintiKarl Doghramji
Nov 29, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chuan-Chia ChangWei-Chung Mao
May 6, 2006·General Hospital Psychiatry·Ozgür OztürkEmre Kumral
Aug 18, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Melody Ryan, John T Slevin
Aug 24, 2006·Sleep Medicine·Christopher J Earley, Richard P Allen
Dec 27, 2006·General Hospital Psychiatry·Nader PerroudCristian Damsa
Jan 2, 2007·The Journal of Clinical Psychiatry·Keiko A Prospero-GarciaGuadalupe Teran-Perez
Jan 17, 2007·Journal of Clinical Psychopharmacology·Harpreet S Duggal, Dattatreya N Mendhekar
Jan 19, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Roberto VetrugnoPasquale Montagna
May 3, 2007·Journal of Neurology·Andrea RomigiMaria Grazia Marciani
May 9, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Pedro Emilio Bermejo VelascoRafael Saez Pinel
Jan 22, 2008·Sleep Medicine·Daniele Lo Coco, Emanuele Cannizzaro
Jan 30, 2008·Pharmacotherapy·Robert Lee PageAndreas A Brieke
May 13, 2008·Journal of Psychiatric Research·Klaus G RottachThomas Messer
Jun 20, 2008·Journal of Psychopharmacology·Seung-Gul KangLeen Kim
Aug 30, 2008·Human Psychopharmacology·Sung-Wan KimJin-Sang Yoon
Nov 18, 2008·Journal of Clinical Psychopharmacology·Maria R Urbano, J Catesby Ware
Apr 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Kristin R BaughmanScott K Ober
May 16, 2009·Journal of Neurology·Pedro Emilio Bermejo
Apr 22, 2010·Current Drug Safety·Shilpa AggarwalMichael Berk
May 14, 2010·Anesthesiology·Mathieu RauxIsabelle Arnulf
May 18, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kuan-Ju ChouMing-Chyi Huang
Nov 26, 2010·European Journal of Clinical Pharmacology·Juan Bolaños-VergarayPilar Piquer
Jul 23, 2011·The Australian and New Zealand Journal of Psychiatry·Saji Joseph Chathanchirayil

❮ Previous
Next ❯

Citations

Aug 11, 2018·Expert Review of Neurotherapeutics·Marco ZucconiLuigi Ferini-Strambi
Jun 4, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·T M OstroumovaV A Parfenov
Aug 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew D Krystal
Feb 18, 2020·European Journal of Clinical Pharmacology·Ann-Cathrine Dalgård DunvaldLars Christian Lund
Feb 2, 2021·JAMA Network Open·Nan HuoMichelle M Mielke
Nov 10, 2020·Tzu Chi Medical Journal·Jamir Pitton Rissardo, Ana Leticia Fornari Caprara
Apr 9, 2021·BMC Psychiatry·Mustafa Abdul KarimPeter M Haddad
Sep 18, 2021·Human Psychopharmacology·Hanan Hany ElrassasMahmoud Morsy
Nov 5, 2021·Nature Reviews. Disease Primers·Mauro ManconiYves Dauvilliers

❮ Previous
Next ❯

Software Mentioned

JHRLSS

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here