Drug-induced skin reactions and acute cutaneous graft-versus-host reaction: a comparative immunohistochemical study

Blut
M DrijkoningenV Desmet

Abstract

Skin biopsies from eight patients with drug-induced dermatitis have been compared with skin biopsies from 16 patients developing skin lesions (acute graft versus host-reaction and/or drug-induced reaction) after bone marrow transplantation. Biopsies were investigated using immunohistochemistry and several monoclonal antibodies. Morphological and immunohistochemical patterns in skin biopsies of both groups were very similar. The only difference seen was a reduced number of epidermal Langerhans cells with poorly developed dendrites in skin biopsies taken from patients who underwent bone marrow transplantation. If the latter finding is due to the cytotoxic drug regimen administered before bone marrow transplantation, as previously stated, we doubt the usefulness of skin biopsies in the differential diagnosis of acute graft-versus-host reaction and drug-induced skin lesions.

References

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Citations

Oct 28, 1998·The American Journal of Dermatopathology·M G FlemingS Kohler
Sep 23, 1997·The American Journal of Surgical Pathology·S KohlerB R Smoller
Apr 29, 1998·Journal of the American Academy of Dermatology·S K BarksdaleR L Barnhill
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S B WooM M Schubert
Jan 1, 1994·The Journal of Dermatology·J OsawaH Nakajima

Related Concepts

Teens
Biopsy
Morbilliform Drug Reaction
Differential Diagnosis
Graft-vs-Host Disease
Graft Vs Host Reaction
Immunocytochemistry
Skin
Bone Marrow Cell Transplantation

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