Drug-induced systemic lupus: revisiting the ever-changing spectrum of the disease using the WHO pharmacovigilance database.

Annals of the Rheumatic Diseases
Laurent ArnaudJoe-Elie Salem

Abstract

Drug-induced lupus (DIL) is an idiosyncratic side effect of treatments in which symptoms overlap with those of systemic lupus erythematosus (SLE). The spectrum of DIL constantly evolves with that of the pharmacopoeia. Here, we used VigiBase, the WHO global individual case safety reports (ICSRs) database, to identify the main drugs associated with DIL. We analysed all ICSRs classified as 'systemic lupus erythematosus' according to the Medical Dictionary for Drug Regulatory Activities term (preferred term level) in VigiBase. The drugs considered in the analysis were those not used to treat SLE, with a positive lower end of the 95% credibility interval for the information component (IC025) ≥0, an indicator value for disproportionate Bayesian reporting. A total of 12 166 DIL ICSRs were identified using VigiBase. From those, 8163 ICSRs reporting on 118 suspected drugs with IC025 ≥0 were extracted. The median age at DIL onset was 49 years and the female to male sex ratio was 4.3. The median delay between start of suspected treatment and DIL occurrence was 172 days. DIL was reported as serious adverse event in 55.4%. Among the 118 suspected drugs, 42 had not been previously reported in association with DIL. The drugs associated with t...Continue Reading

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Citations

Feb 15, 2019·Annals of the Rheumatic Diseases·Robert L Rubin
Oct 31, 2019·Dermatologic Therapy·Sybille GiraudMahtab Samimi
Sep 3, 2020·JAMA Dermatology·Jeanette Halskou HaugaardAlexander Egeberg
Aug 19, 2020·Chinese Medical Journal·Yong FanZhuo-Li Zhang
Nov 14, 2019·Arthritis Research & Therapy·Michel De Bandt
Nov 5, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nida Siddiqi, Ibrahim F Shatat
Sep 9, 2020·Expert Opinion on Drug Metabolism & Toxicology·Elisa MolinelliAnnamaria Offidani
Oct 22, 2020·Expert Opinion on Biological Therapy·Bethan Goulden, David Isenberg
Nov 21, 2020·Expert Opinion on Biological Therapy·Ana Lorenzo-Vizcaya, David A Isenberg
Jan 5, 2021·Expert Review of Clinical Immunology·Samuel de Oliveira AndradeSimone Appenzeller
Jan 15, 2021·Journal of Clinical Medicine·Matteo Piga, Laurent Arnaud
Oct 15, 2020·Annals of the Rheumatic Diseases·Antonis FanouriakisDimitrios T Boumpas
Feb 18, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Elisabetta ChessaAlberto Cauli
Apr 15, 2021·Lupus Science & Medicine·Alain CornetLaurent Arnaud
Jun 14, 2019·Annals of the Rheumatic Diseases·Emanuel RaschiFabrizio De Ponti
Jun 23, 2021·BMC Veterinary Research·Jérémy BéguinChristelle Maurey
Dec 24, 2021·Deutsches Ärzteblatt International·Igor KremenevskiMartin Raithel

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