Drug-induced thyrotoxic periodic paralysis

The Annals of Pharmacotherapy
Michael P Kane, Robert S Busch

Abstract

To report a case of iodine-induced (Jod-Basedow) hyperthyroidism leading to thyrotoxic periodic paralysis (TPP). A 64-year-old white male, one day status-post-cardiac catheterization, presented to the local emergency department with profound weakness of his extremities and an inability to stand on his own. Pertinent laboratory test results included a potassium level of 3.0 mEq/L. Treatments of oral and intravenous potassium supplementation resulted in his complete recovery. Two days later he was diagnosed with hyperthyroidism and subsequently treated with nadolol 40 mg daily and methimazole 20 mg daily. At time of writing, the patient remained euthyroid, receiving no antithyroid medications. There had been no further reports of paralysis in the 6 years since his original presentation. The Naranjo probability scale indicated a probable relationship between the patient's episode of TPP and his exposure to the iodinated contrast dye. TPP is an uncommon manifestation in white patients with hyperthyroidism. Iodine-induced TPP is even more rare, with only 2 such cases reported as of November 2, 2005. In this case, Jod-Basedow hyperthyroidism was induced by the iodine-containing dye that the patient received during cardiac catheteriza...Continue Reading

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Citations

Feb 21, 2014·Journal of Pharmacology & Pharmacotherapeutics·Poonam AgrawalHimanshu Madaan
Aug 25, 2012·Endocrine·Henrik FalhammarJan Calissendorff
Nov 22, 2013·The Annals of Pharmacotherapy·Cemil IzgiFusun Gunesdogdu
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