Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administration.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Sietse JonkmanBarry J Everitt

Abstract

Compulsive drug seeking, which is characterized by continued instrumental effort despite contingent punishment, has been shown to emerge after extended drug self-administration. Exactly what aspect of drug self-administration drives the appearance of addictive behavior is unclear, but the mechanistic explanations that have been offered differ in one key respect. On one hand, it has been suggested that dysfunctional conditioning during self-administration drives unrealistic reward expectations, ultimately producing resistance to punishment. If this is indeed the pathological process that drives compulsive behavior, then compulsivity should be apparent only in the presence of the pavlovian and instrumental stimuli that underwent frequent pairing with the drug reward. On the other hand, it has also been suggested that extended drug intake produces general changes to reward and decision-making circuits that manifest as compulsive drug seeking. Unfortunately, conditioning history and drug intake are generally intrinsically intertwined. However, here we used an animal model of compulsive cocaine seeking to selectively manipulate drug intake and the degree of conditioning in the test context, to investigate which of the two is more im...Continue Reading

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Citations

Jun 12, 2013·Neuropharmacology·George F KoobOlivier George
Sep 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sietse Jonkman, Paul J Kenny
Nov 14, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Schahram Akbarian, Eric J Nestler
Jul 11, 2013·Behavioural Pharmacology·Scott Edwards, George F Koob
Apr 8, 2014·Nature Neuroscience·Ingo WilluhnPaul E M Phillips
Jun 28, 2015·Neuroscience and Biobehavioral Reviews·Florence AllainAnne-Noël Samaha
Jan 18, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn FigeeDamiaan Denys
Aug 9, 2015·Annual Review of Psychology·Barry J Everitt, Trevor W Robbins
Oct 20, 2012·Reviews in the Neurosciences·Heidi M B Lesscher, Louk J M J Vanderschuren
Nov 26, 2015·Biological Psychiatry·Eric DucretDavid Belin
Mar 19, 2014·Trends in Neurosciences·Bart A Ellenbroek, Bibinaz Ghiabi
Feb 27, 2013·Neuroscience and Biobehavioral Reviews·Barry J Everitt, Trevor W Robbins
Jul 26, 2014·Drug and Alcohol Dependence·Jules H W LimpensLouk J M J Vanderschuren
Jun 15, 2016·Neurobiology of Learning and Memory·Eric A Thrailkill, Mark E Bouton
Apr 11, 2017·Brain Structure & Function·Ping GaoPieter Voorn
Jan 21, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry J EverittDavid Belin
Apr 29, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brooke E SchmeichelCandice Contet
Jul 7, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melissa S MonseyJane R Taylor
Jan 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lee Hogarth
Apr 2, 2020·Nature Reviews. Neuroscience·Christian LüscherBarry J Everitt
Jun 28, 2018·Psychopharmacology·Udita DattaWenLin Sun
Apr 19, 2017·Current Neurology and Neuroscience Reports·Isabel García-GarcíaAlain Dagher
Apr 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mickael DegouletYann Pelloux
Sep 10, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rachel J Smith, Lillian S Laiks
Mar 6, 2021·Annual Review of Neuroscience·Christian Lüscher, Patricia H Janak

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