Drug intelligence based on organic impurities in illicit MA samples

Forensic Science International : Synergy
L DujourdyJoseph S Bozenko

Abstract

One major objective of the European project "Collaborative Harmonisation of Methods for Profiling of Amphetamine Type Stimulants" (CHAMP), funded by the sixth framework programme of the European Commission, consisted of the harmonisation of a gas chromatography/mass spectrometry (GC/MS) method for the analysis of organic impurities found in illicit methamphetamine (MA) samples in a drug intelligence perspective. Statistical analysis provided a selection of pertinent variables among the 43 organic impurities identified in the chromatograms. As for the 3,4-MethyleneDioxyMethAmphetamine (MDMA) study, correlation coefficients were used as a discrimination tool between populations of linked samples (from the same seizure) and unlinked samples (from different seizures). It was also shown that correlation measurements based on Pearson and cosine functions applied to the data pre-treated by normalisation to the sum of peak responses followed by the square root provided excellent discrimination between the two populations. The organic impurities profiling method was proved to be relevant for the characterization of samples from different seizures and their synthesis route patterns.

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Citations

Jul 20, 2011·Analytical and Bioanalytical Chemistry·Blagoj MitrevskiPhilip J Marriott
Apr 20, 2013·Forensic Science International : Synergy·John D PowerPierce Kavanagh
Feb 21, 2013·Forensic Science International : Synergy·Yuko T IwataHiroyuki Inoue
Nov 7, 2012·Forensic Science International : Synergy·Sanggil ChoeSuncheun Kim
Sep 28, 2010·Forensic Science International : Synergy·Pierre EsseivaFrederic Anglada
Jan 9, 2010·Forensic Science International : Synergy·François MarclayChristophe Saudan
Feb 28, 2014·Rapid Communications in Mass Spectrometry : RCM·Natasha StojanovskaShanlin Fu
Jan 21, 2014·Science & Justice : Journal of the Forensic Science Society·Marie MorelatoClaude Roux
Jan 13, 2015·Science & Justice : Journal of the Forensic Science Society·Nicola M BeckettSarah L Cresswell
Feb 1, 2017·Journal of Separation Science·Nafiseh ShekariKourosh Tabar Heidar
Mar 2, 2018·Drug Testing and Analysis·Cuimei LiuZhendong Hua
Jul 9, 2020·Forensic Science International : Synergy·Isaac OnokaLaurence Dujourdy
May 9, 2009·Analytical Chemistry·T A BrettellJ R Almirall
Jun 11, 2021·Forensic Science International : Synergy·Susanna MeolaPierre Esseiva
Aug 18, 2021·Drug Testing and Analysis·Michael Collins

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