Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

Expert Opinion on Drug Metabolism & Toxicology
Claudiu T Supuran

Abstract

Carbonic anhydrase inhibitors (CAIs) of the sulfonamide and sulfamate type are clinically used drugs as diuretics, antiglaucoma, antiepileptic, antiobesity and anti-high altitude disease agents. Anticancer agents based on CAIs are also in clinical development for the management of hypoxic, metastatic tumors. Acetazolamide, methazolamide, dichlorophenamide, dorzolamide and brinzolamide are mainly used as antiglaucoma drugs, sulthiame, topiramate and zonisamide as antiepileptic/antiobesity agents, celecoxib and polmacoxib are dual carbonic anhydrase/cycloxygenase inhibitors. Girentuximab, a monoclonal antibody and SLC-0111, a sulfonamide inhibitor, are in clinical trials as anticancer agents. The drug interactions with many classes of pharmacological agents are reviewed. Some of these drugs, such as acetazolamide, topiramate and celecoxib show a large number of interactions with non-steroidal anti-inflammatory drugs (NSAIDs), diuretics, antiepileptics, immunosupressants, anticholinesterase drugs, β-blockers, anesthetics, oral contraceptives, anticancer agents, antifungals, anti-mycobacterials, lithium, metformin and clopidogrel. The multiple drug interactions in which CAIs are involved should be carefully considered when such dru...Continue Reading

References

Oct 1, 1978·American Journal of Ophthalmology·C J AndersonR J Sturm
Nov 1, 1986·Clinical Pharmacology and Therapeutics·K R SweeneyP A Kramer
May 21, 1998·Clinical Pharmacokinetics·R C Sachdeo
Dec 31, 1998·Archives of Ophthalmology·K F TabbaraG Foulds
Nov 7, 1999·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·F BrigantiC T Supuran
Jan 17, 2002·The Annals of Pharmacotherapy·A A Fisher, D G Le Couteur
Aug 2, 2003·Clinical Pharmacology and Therapeutics·Ulrike WernerKay Brune
Jan 22, 2004·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Makoto AraieHideki Origasa
Sep 7, 2004·Journal of Clinical Psychopharmacology·Gebrehiwot Abraham, J Owen
Sep 10, 2004·Clinical Pharmacokinetics·Meir BialerStefan Schwabe
Oct 30, 2004·Seizure : the Journal of the British Epilepsy Association·Ilo E Leppik
Mar 15, 2005·Molecular Membrane Biology·Patricio E MorganJoseph R Casey
Nov 22, 2005·Drug and Chemical Toxicology·Gregg D CapponM E Hurtt
Nov 25, 2006·The Journal of Physiology·Bernardo V AlvarezJoseph R Casey
May 17, 2007·Current Topics in Medicinal Chemistry·Anne ThiryBernard Masereel
Jan 3, 2008·Nature Reviews. Drug Discovery·Claudiu T Supuran
Feb 9, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Pat AudiaJames F Winchester
Feb 16, 2008·The American Journal of the Medical Sciences·Anne M BaciewiczTimothy H Self
Mar 14, 2008·Current Pharmaceutical Design·Giuseppina De SimoneClaudiu T Supuran
Sep 23, 2008·Clinical Therapeutics·Kevin Yi-Lwern YapAlexandre Chan
Sep 30, 2008·Bioorganic & Medicinal Chemistry·Esra BayramClaudiu T Supuran
Oct 7, 2008·Journal of Clinical Pharmacy and Therapeutics·J F KnudsenC M Flowers
Nov 14, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Dharmarajan SriramPerumal Yogeeswari
Dec 17, 2008·Journal of Molecular Biology·Christine SchlickerClemens Steegborn
Feb 12, 2009·Journal of the American Chemical Society·Alfonso MarescaClaudiu T Supuran
Feb 12, 2009·Epilepsy & Behavior : E&B·Thomas G BurnsMorris Cohen
Feb 24, 2009·Bioorganic & Medicinal Chemistry·Murat SentürkClaudiu T Supuran
Apr 3, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Peter EbbesenAndrea Scozzafava
Dec 22, 2009·Expert Review of Neurotherapeutics·Cecilie Johannessen Landmark, Philip N Patsalos
Jul 2, 2010·Journal of Medicinal Chemistry·Fabrizio CartaClaudiu T Supuran
Nov 16, 2010·International Journal of Obstetric Anesthesia·K FujiiY Hatano

❮ Previous
Next ❯

Citations

May 24, 2016·Expert Review of Neurotherapeutics·Claudiu T Supuran
Jun 9, 2016·Journal of Agricultural and Food Chemistry·Giosuè CostaStefano Alcaro
Jul 9, 2016·Expert Opinion on Therapeutic Patents·Carrie Lomelino, Robert McKenna
Oct 27, 2016·Expert Opinion on Drug Discovery·Claudiu T Supuran
Feb 6, 2017·Analytical Biochemistry·Joana SmirnovienėDaumantas Matulis
Jun 29, 2017·Expert Opinion on Drug Safety·Jed Asher Lusthaus, Ivan Goldberg
Nov 16, 2017·Metabolites·Claudiu T Supuran, Clemente Capasso
Jan 16, 2018·British Journal of Clinical Pharmacology·Iva Hoffmanová, Daniel Sánchez
Jul 6, 2018·Expert Opinion on Therapeutic Patents·Claudiu T Supuran, Clemente Capasso
Sep 4, 2018·Expert Opinion on Therapeutic Patents·Claudiu T Supuran
Sep 16, 2018·Expert Opinion on Therapeutic Patents·Claudiu T Supuran
Nov 15, 2018·Expert Opinion on Investigational Drugs·Claudiu T Supuran
Nov 4, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Daniela VulloClaudiu T Supuran
Dec 18, 2018·Expert Opinion on Therapeutic Patents·Giuseppina De Simone
Feb 7, 2019·Pharmacotherapy·Salia FarrokhEljim Tesoro
Aug 23, 2019·Expert Opinion on Drug Discovery·Alessio Nocentini, Claudiu T Supuran
Dec 6, 2019·Fundamental & Clinical Pharmacology·Poliana de Araujo OliveiraBruno Guimarães Marinho
Nov 7, 2019·São Paulo Medical Journal = Revista Paulista De Medicina·Bianca Menezes DiasAdriano Max Moreira Reis
Dec 12, 2019·Revista brasileira de enfermagem·Fernanda Auxiliadora TrevizaniSueli Marques
Mar 17, 2020·Expert Opinion on Drug Metabolism & Toxicology·Claudiu T Supuran
Aug 19, 2020·Expert Opinion on Therapeutic Patents·Claudiu T Supuran, Clemente Capasso
Oct 18, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Manuel A LlanosLuciana Gavernet
Jun 23, 2018·Journal of Neurology·Hilde M H Braakman, Jakko van Ingen
Aug 12, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Claudiu T Supuran
Oct 18, 2020·Metabolites·Andrea AngeliClaudiu T Supuran
Jan 13, 2021·International Journal of Molecular Sciences·Viviana De LucaClemente Capasso
Apr 6, 2021·Frontiers in Microbiology·Cristina CampestreClemente Capasso
May 1, 2021·International Journal of Molecular Sciences·Claudiu T Supuran, Clemente Capasso
Jul 20, 2021·Cellular and Molecular Neurobiology·Qiang YueChang Zeng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Expert Opinion on Therapeutic Patents
Fabrizio CartaClaudiu T Supuran
Journal of Enzyme Inhibition and Medicinal Chemistry
Asif Husain, Diwakar Madhesia
Sub-cellular Biochemistry
Andrea Scozzafava, Claudiu T Supuran
© 2022 Meta ULC. All rights reserved