Feb 16, 2016

Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

Expert Opinion on Drug Metabolism & Toxicology
Claudiu T Supuran

Abstract

Carbonic anhydrase inhibitors (CAIs) of the sulfonamide and sulfamate type are clinically used drugs as diuretics, antiglaucoma, antiepileptic, antiobesity and anti-high altitude disease agents. Anticancer agents based on CAIs are also in clinical development for the management of hypoxic, metastatic tumors. Acetazolamide, methazolamide, dichlorophenamide, dorzolamide and brinzolamide are mainly used as antiglaucoma drugs, sulthiame, topiramate and zonisamide as antiepileptic/antiobesity agents, celecoxib and polmacoxib are dual carbonic anhydrase/cycloxygenase inhibitors. Girentuximab, a monoclonal antibody and SLC-0111, a sulfonamide inhibitor, are in clinical trials as anticancer agents. The drug interactions with many classes of pharmacological agents are reviewed. Some of these drugs, such as acetazolamide, topiramate and celecoxib show a large number of interactions with non-steroidal anti-inflammatory drugs (NSAIDs), diuretics, antiepileptics, immunosupressants, anticholinesterase drugs, β-blockers, anesthetics, oral contraceptives, anticancer agents, antifungals, anti-mycobacterials, lithium, metformin and clopidogrel. The multiple drug interactions in which CAIs are involved should be carefully considered when such dru...Continue Reading

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Mentioned in this Paper

Topiramate
Sulfamic acid, zinc (2: 1) salt
Monoclonal Antibodies
Antiglaucoma medications
Carbonic Anhydrase Inhibitors [MoA]
Topamax
Metformin
Antineoplastic Agents
Dermatofibrosarcoma Protuberans
Thiophenes

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