Drug interactions between antiretroviral medications and medications used in the treatment of drug addiction: research needs.

The American Journal on Addictions
Jag H Khalsa, Ahmed Elkashef

Abstract

Today substance dependence is one of the major public health problems in the world with millions of people abusing legal and illegal drugs. In addition, almost one-third of the world's population suffers with one or more infections. Both drugs of abuse and infections are associated with serious medical and health consequences, some of which may be exacerbated by the occurrence of pharmacokinetic and/or pharmacodynamic interactions between medications used in the treatment of these conditions when they co-occur. This review briefly discusses issues surrounding clinical management related to drug interactions experienced by substance abusing patients. The emphasis of this paper is on the research needed to further study the extent, nature, and underlying molecular/genetic mechanism(s) of interactions between drugs of abuse, medications used in the treatment of drug addiction, and co-occurring infections.

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Mar 1, 2011·Journal of Substance Abuse Treatment·Aaron M KippHan-Zhu Qian
Mar 25, 2015·Biochemical Pharmacology·Scott D CampbellEvan D Kharasch
Oct 27, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna FerrariEmilio Sternieri
Mar 7, 2017·Clinical Pharmacology in Drug Development·Jag H KhalsaGene Morse
Sep 27, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Evan D Kharasch, Kristi Stubbert
Apr 24, 2015·The Annals of Pharmacotherapy·Leonie MeemkenAnton Gillessen

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