Drug interactions involving antiepileptic drugs: assessment of the consistency among three drug compendia and FDA-approved labels

Epilepsy & Behavior : E&B
Dana EksteinSara Eyal

Abstract

Interactions of antiepileptic drugs (AEDs) with other substances may lead to adverse effects and treatment failure. To avoid such interactions, clinicians often rely on drug interaction compendia. Our objective was to compare the concordance for twenty-two AEDs among three drug interaction compendia (Micromedex, Lexi-Interact, and Clinical Pharmacology) and the US Food and Drug Administration-approved product labels. For each AED, the overall concordance among data sources regarding existence of interactions and their classification was poor, with less than twenty percent of interactions listed in all four sources. Concordance among the three drug compendia decreased with the fraction of the drug excreted unchanged and was greater for established inducers of hepatic drug-metabolizing enzymes than for the drugs that are not inducers (R-square=0.83, P<0.01). For interactions classified as contraindications, major, and severe, concordance among the four data sources was, in most cases, less than 30%. Prescribers should be aware of the differences between drug interaction sources of information for both older AEDs and newer AEDs, in particular for those AEDs which are not involved in hepatic enzyme-mediated interactions.

References

Sep 1, 1979·European Journal of Clinical Pharmacology·P J PentikäinenA Penttilä
Jun 2, 1998·The Annals of Pharmacotherapy·G D Anderson
May 6, 2006·Acta Neurologica Scandinavica·I TsiropoulosJ Hallas
Jul 18, 2006·British Journal of Clinical Pharmacology·Andrew OwenMunir Pirmohamed
Dec 2, 2006·Research in Social & Administrative Pharmacy : RSAP·Jeff J GuoOceana Vu
Dec 15, 2006·British Journal of Clinical Pharmacology·Agnes I Vitry
Apr 11, 2007·Seizure : the Journal of the British Epilepsy Association·Cecilie Johannessen LandmarkSvein I Johannessen
Aug 1, 2008·Current Clinical Pharmacology·Sorin E Leucuta, Laurian Vlase
Dec 22, 2009·Expert Review of Neurotherapeutics·Cecilie Johannessen Landmark, Philip N Patsalos
Jan 19, 2011·Clinical Pharmacokinetics·Garry G GrahamKenneth M Williams
Mar 26, 2011·Epilepsy Research·Cecilie Johannessen LandmarkSvein I Johannessen
Feb 22, 2012·British Journal of Clinical Pharmacology·Sebastian HärtterPaul A Reilly
May 23, 2012·Seizure : the Journal of the British Epilepsy Association·Jennifer M NicholasMartin C Gulliford
Sep 6, 2012·British Journal of Clinical Pharmacology·Sebastian HärtterPaul Reilly
Aug 14, 2013·Epilepsy & Behavior : E&B·Mohamad KarouniCecilie Johannessen Landmark
Sep 21, 2013·Nature Reviews. Drug Discovery·Wolfgang LöscherDieter Schmidt
Apr 17, 2014·Epilepsy & Behavior : E&B·Scott MintzerKathleen Foley

❮ Previous
Next ❯

Citations

Jan 6, 2016·Seizure : the Journal of the British Epilepsy Association·Yifat RothSara Eyal
Oct 25, 2017·JAAPA : Official Journal of the American Academy of Physician Assistants·Mikhail Y AkbashevDaniel D Dressler
Jun 4, 2019·Pharmaceutical Research·Erez Berman, Sara Eyal
Feb 24, 2017·BMC Medical Informatics and Decision Making·Katrina M RomagnoliHarry Hochheiser
Mar 14, 2019·Behavioural Neurology·Ebrahim M YimerAbadi Kahsu Gebre
Mar 26, 2021·Frontiers in Pharmacology·Harry HochheiserRichard D Boyce

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Advances in Experimental Medicine and Biology
Z P Qu
The Journal of the Maine Medical Association
T R Browne
Clinical Neuropharmacology
Carl W Bazil, Timothy A Pedley
Clinical Neuropharmacology
J Bruni, P S Albright
© 2021 Meta ULC. All rights reserved