Drug interactions with oral sulphonylurea hypoglycaemic drugs

J M Hansen, L K Christensen


The effect of the oral sulphonylurea hypoglycaemic drugs may be influenced by a large number of other drugs. Some of these combinations (e.g. phenylbutazone, sulphaphenazole) may result in cases of severe hypoglycaemic collapse. Tolbutamide and chlorpropamide should never be given to a patient without a prior careful check of which medicaments are already being given. Similarly, no drug should be given to a diabetic treated with tolbutamide and chlorpropamide without consideration of the possibility of interaction phenomena.


Jan 1, 1985·European Journal of Clinical Pharmacology·E Zylber-KatzM Levy
Aug 1, 1980·European Journal of Clinical Pharmacology·U Bergman Ostman
Mar 31, 1992·European Journal of Pharmacology·D Fückel, E Petzinger
Jan 1, 1981·Pharmacology & Therapeutics·L Aarons
Jan 1, 1990·Pharmacology & Therapeutics·M Barry, J Feely
Jun 16, 2000·European Journal of Pharmacology·Y UwaiK Inui
Apr 8, 1998·The Journal of Pharmacy and Pharmacology·N NishimuraK Iwamoto
Mar 19, 1988·British Medical Journal·M J Brodie, J Feely
Feb 24, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·N NishimuraK Iwamoto
Apr 2, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Nobuhiro Nishimura
Nov 28, 1986·Journal of Chromatography·H EmilssonI Christenson
Jan 1, 1981·Drug Metabolism Reviews·M T Kenny, B Strates
Jun 27, 2013·Journal of Pharmaceutical Sciences·Tonika Bohnert, Liang-Shang Gan
Jan 11, 2012·Molecular Aspects of Medicine·Gabriella FanaliPaolo Ascenzi
Sep 20, 1985·The American Journal of Medicine·J M Feldman
Aug 29, 1986·The American Journal of Cardiology·B D QuartA J Wood
Aug 1, 1987·British Journal of Clinical Pharmacology·H S PurbaM L Orme
Feb 1, 1985·British Journal of Clinical Pharmacology·K StoeckelU Hennes
Jul 1, 1982·British Journal of Clinical Pharmacology·P J MorrisonV A John
Oct 1, 1981·British Journal of Clinical Pharmacology·P B AndreasenP Bouchelouche
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Nobuhiro NishimuraKikuo Iwamoto
Nov 2, 1989·The New England Journal of Medicine·J E Gerich
Apr 1, 1984·Drug Intelligence & Clinical Pharmacy·A M Baciewicz, W B Swafford

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.